ReviewMedGenMed : Medscape general medicine2004
Telomeres, telomerase, and tumorigenesis--a review.
Review in MedGenMed : Medscape general medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress.European archives of psychiatry and clinical neuroscience · 2026Review
- Article
- Article
- An Update to Hallmarks of Cancer.Cureus · 2022Review
- Molecular insight of dyskeratosis congenita: Defects in telomere length homeostasis.Journal of clinical and translational research · 2022Review
- Dual effect of Sapogenins extracted fromMolecular biology research communications · 2021Article
- Review
- Relationship of Anxiety, Inflammation, and Telomere Length in Postpartum Women: A Pilot Study.Biological research for nursing · 2020Article
- Safety evaluation of conditionally immortalized cells for renal replacement therapy.Oncotarget · 2019Article
- Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients.Cells · 2019Article
- Down regulation of human telomerase reverse transcriptase (hTERT) expression by BIBR1532 in human glioblastoma LN18 cells.Cytotechnology · 2018Article
- The relationship between telomere length and clinicopathologic characteristics in colorectal cancers among Tunisian patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- The correlation between telomerase activity and Bax/Bcl-2 ratio in valproic acid-treated MCF-7 breast cancer cell line.Iranian journal of basic medical sciences · 2015Article
- Article
- Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton.International journal of oncology · 2013Article
- Establishment and characterization of immortalized human amniotic epithelial cells.Cellular reprogramming · 2013Article
- Telomeres and atherosclerosis.Cardiovascular journal of Africa · 2012Review
- Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.Carcinogenesis · 2011Article
- Genetic variants in telomere-maintaining genes and skin cancer risk.Human genetics · 2011Article
- An integrated molecular dynamics (MD) and experimental study of higher order human telomeric quadruplexes.Biopolymers · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human telomeres function as a protective structure capping both ends of the chromosome. They are composed of long, repetitive sequences of TTAGGG, associated with a variety of telomere-binding proteins. Telomeres protect the chromosomes from end-to-end fusion, recombination, and degradation, all events that can lead to cell death. At cell replication, telomeres cannot be completely replicated. They are gradually shortened, and when the telomeres reach a critical threshold, cell replication is arrested in what is called "replicative senescence." Thus, telomeres act as an intrinsic "counting" mechanism of the cell's aging process. Telomerase is an enzymatic ribonucleoprotein complex that acts as a reverse transcriptase in the elongation of telomeres. Telomerase activity is almost absent in somatic cells, but it is detected in embryonic stem cells and in the vast majority of tumor cells. Tumor cells, in fact, may contain short and stable telomeres that confer immortality to the cancer cells, which are thus able to replicate indefinitely. The deregulation of telomeres thus plays an important role in the relationship between premature aging syndrome and cancer. This review describes the recent advances in the molecular characterization of telomeres, the regulation of telomerase
Indexed as
Identifiers
15520642PMC1435592W2412643659What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.