ArticleNucleic acids research2004
Alleviation of restriction by DNA condensation and non-specific DNA binding ligands.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- RecA-dependent or independent recombination of plasmid DNA generates a conflict with the host EcoKI immunity by launching restriction alleviation.Nucleic acids research · 2024Article
- How bacteria control the CRISPR-Cas arsenal.Current opinion in microbiology · 2018Review
- Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Is photocleavage of DNA by YOYO-1 using a synchrotron radiation light source sequence dependent?European biophysics journal : EBJ · 2011Article
- An investigation of the structural requirements for ATP hydrolysis and DNA cleavage by the EcoKI Type I DNA restriction and modification enzyme.Nucleic acids research · 2011Article
- Roles of PriA protein and double-strand DNA break repair functions in UV-induced restriction alleviation in Escherichia coli.Genetics · 2006Article
- Strong physical constraints on sequence-specific target location by proteins on DNA molecules.Nucleic acids research · 2006Article
- Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I.The EMBO journal · 2005Article
- Ligand-induced DNA condensation: choosing the model.Biophysical journal · 2005Article
- On the DNA cleavage mechanism of Type I restriction enzymes.Nucleic acids research · 2005Article
- StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI.Nucleic acids research · 2005Article
- Subunit assembly modulates the activities of the Type III restriction-modification enzyme PstII in vitro.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During conditions of cell stress, the type I restriction and modification enzymes of bacteria show reduced, but not zero, levels of restriction of unmethylated foreign DNA. In such conditions, chemically identical unmethylated recognition sequences also occur on the chromosome of the host but restriction alleviation prevents the enzymes from destroying the host DNA. How is this distinction between chemically identical DNA molecules achieved? For some, but not all, type I restriction enzymes, alleviation is partially due to proteolytic degradation of a subunit of the enzyme. We identify that the additional alleviation factor is attributable to the structural difference between foreign DNA entering the cell as a random coil and host DNA, which exists in a condensed nucleoid structure coated with many non-specific ligands. The type I restriction enzyme is able to destroy the 'naked' DNA using a complex reaction linked to DNA translocation, but this essential translocation process is inhibited by DNA condensation and the presence of non-specific ligands bound along the DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.