ArticleNucleic acids research2004
Complex patterns of transcription at the insertion site of a retrotransposon in the mouse.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 108 citations in OpenAlex.
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- Ectopic expression of the Stabilin2 gene triggered by an intracisternal A particle (IAP) element in DBA/2J strain of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Additional ORFs in Plant LTR-Retrotransposons.Frontiers in plant science · 2020Review
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- LTRs of Endogenous Retroviruses as a Source of Tbx6 Binding Sites.Frontiers in chemistry · 2017Article
- Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration.Mobile DNA · 2017Article
- Detection of differential DNA methylation in repetitive DNA of mice and humans perinatally exposed to bisphenol A.Epigenetics · 2016Article
- Genetic and epigenetic variation among inbred mouse littermates: identification of inter-individual differentially methylated regions.Epigenetics & chromatin · 2015Article
- Longitudinal epigenetic drift in mice perinatally exposed to lead.Epigenetics · 2014Article
- An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition.Nucleic acids research · 2014Article
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- The use of mouse models to study epigenetics.Cold Spring Harbor perspectives in biology · 2013Review
- LINE-1 activation and epigenetic silencing of suppressor genes in cancer: Causally related events?Mobile genetic elements · 2013Article
- Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation.Carcinogenesis · 2013Review
- How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Phylogenetic and DNA methylation analysis reveal novel regions of variable methylation in the mouse IAP class of transposons.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report that transcriptional effects of the insertion of a retrotransposon can occur simultaneously both upstream and downstream of the insertion site. We have identified an intra-cisternal A particle (IAP) retrotransposon in intron 6 of a gene that we have named Cabp (CDK5 activator binding protein). The presence of the IAP is associated with an aberrant transcript initiating from a cryptic promoter in the IAP, reading out into the adjacent Cabp gene sequence. The expression of this transcript is highly variable among isogenic mice within the C57BL/6J strain and so Cabp(IAP) can be classified as a metastable epiallele. As expected, the presence or absence of the transcript correlates with differential DNA methylation of the 5' LTR of the IAP. More surprisingly, in mice where the retrotransposon is unmethylated and presumably transcriptionally active, we find a number of short Cabp transcripts which initiate at the normal 5' end of the gene but terminate prematurely, just 5' of the retrotransposon. This is the first report of a retrotransposon having both upstream and downstream effects on transcription at the site of insertion and it suggests that alternative polyadenylation may sometimes be caused by a downstream convergent transcription unit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.