ArticleGenetics2005
Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Association between polymorphisms in the beta2-adrenergic receptor gene with myocardial infarction and ischaemic stroke in women.Thrombosis and haemostasis · 2009Trial
- Review
- ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease.Genetics and molecular biology · 2015Article
- Network medicine analysis of COPD multimorbidities.Respiratory research · 2014Article
- Relationship between polymorphisms in beta -2 adrenergic receptor gene and ischemic stroke in North Indian Population: a hospital based case control study.BMC research notes · 2014Article
- Orthostatic blood pressure dysregulation and polymorphisms of β-adrenergic receptor genes in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.Aging cell · 2012Article
- The genomic architecture of sporadic heart failure.Circulation research · 2011Review
- Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women.Headache · 2009Article
- Association of beta-1 and beta-2 adrenergic receptor gene polymorphisms with myocardial infarction.Journal of clinical laboratory analysis · 2009Article
- Pharmacogenetics of the human beta-adrenergic receptors.The pharmacogenomics journal · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Polymorphisms in the beta2 adrenergic receptor (ADRB2), in particular G16R, Q27E, and T164I, have been implicated in the pathogenesis of cardiovascular and metabolic phenotypes. However, no prospective, genetic-epidemiological data are available on the risk of cardiovascular disease associated with these variants. Using DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we evaluated the G16R, Q27E, and T164I polymorphisms among 523 individuals who subsequently developed myocardial infarction and among 2092 individuals who remained free of reported cardiovascular events during follow-up. The haplotype frequency distribution was significantly different among cases and controls (chi(2)(7d.f.) = 20.92, P = 0.0039). Haplotype-based logistic regression, adjusting for age, smoking, and randomized treatment group, indicated that G16-Q27-I164 (odds ratio 0.178, 95% C.I. 0.043-0.737, P = 0.017) and (non-G16-Q27)-T164 (odds ratio 1.235, 95% C.I. 1.031-1.480, P = 0.022) haplotypes were significantly associated with altered risk of myocardial infarction. These findings remained after further adjustment for BMI, history of hypertension, and presence or absence of diabetes. In conclusion, variation in haplotype frequencies for the beta2 adrenergic receptor gene was found to be associated with risk of myocardial infarction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.