ArticleGenetics2005
Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- "A fly appeared": sable, a classic Drosophila mutation, maps to Yippee, a gene affecting body color, wings, and bristles.G3 (Bethesda, Md.) · 2022Article
- The Role of Insulators in Transgene Transvection inGenetics · 2019Article
- Study of the Ability of the gypsy Insulator to Stabilize Amplification of the chorion Replication Origin of Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2018Article
- Article
- EAST affects the activity of Su(Hw) insulators by two different mechanisms in Drosophila melanogaster.Chromosoma · 2017Article
- LTR sequence of the MDG4 retrotransposon contains the MAD protein binding site that affects the east-dependent repression.Doklady. Biochemistry and biophysics · 2017Article
- Article
- Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements.Nucleic acids research · 2008Article
- Context differences reveal insulator and activator functions of a Su(Hw) binding region.PLoS genetics · 2008Article
- Drosophila gypsy insulator and yellow enhancers regulate activity of yellow promoter through the same regulatory element.Chromosoma · 2008Article
- Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila melanogaster.Genetics · 2006Article
- Study of long-distance functional interactions between Su(Hw) insulators that can regulate enhancer-promoter communication in Drosophila melanogaster.Molecular and cellular biology · 2006Article
- Pairing between gypsy insulators facilitates the enhancer action in trans throughout the Drosophila genome.Molecular and cellular biology · 2005Article
- The Functions and Mechanisms of Action of Insulators in the Genomes of Higher Eukaryotes.Acta naturaeArticle
- A study of barrier activity of 1A2 insulator of Drosophila melanogaster.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulator element from the gypsy transposon is a DNA sequence that blocks activation of a promoter by a transcriptional enhancer when placed between them. The insulator contains reiterated binding sites for the Suppressor of Hairy-wing [Su(Hw)] zinc-finger protein. A protein encoded by another gene, modifier of mdg4 [mod(mdg4)], is also required for the enhancer-blocking activity of the Su(Hw) insulator. Here we present evidence that the Su(Hw) insulator activates a weakened yellow promoter at a distance. Deletion of the upstream promoter region (UPR), located close by the TATA box, significantly reduces yellow expression. The Su(Hw) insulator placed at different positions relative to the yellow promoter partially compensates for loss of the UPR. Su(Hw) is able to stimulate yellow expression even if it is located at a 5-kb distance from the promoter. The stimulatory activity depends on the number of Su(Hw)-binding sites. Mutational analysis demonstrates that only the DNA-binding domain and adjacent regions of the Su(Hw) protein are required for stimulation of yellow transcription.
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