ArticleThe Journal of cell biology2004
A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations.PLoS computational biology · 2025Article
- Deciphering the Molecular Adapting Mechanism of Lactic Acid-TolerantFoods (Basel, Switzerland) · 2025Article
- Molecular dynamics simulations of a multicellular model with cell-cell interactions and Hippo signaling pathway.PLoS computational biology · 2024Article
- When yeast cells change their mind: cell cycle "Start" is reversible under starvation.The EMBO journal · 2023Article
- FAR1/FHY3 Transcription Factors Positively Regulate the Salt and Temperature Stress Responses inFrontiers in plant science · 2022Article
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
- Exploring the evolution of multicellularity inEcology and evolution · 2018Article
- Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks.Cell systems · 2016Article
- Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast.Scientific reports · 2016Article
- Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.Nature communications · 2016Article
- Experimental testing of a new integrated model of the budding yeast Start transition.Molecular biology of the cell · 2015Article
- Article
- Systematic identification of cell size regulators in budding yeast.Molecular systems biology · 2014Article
- Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1.Current biology : CB · 2014Article
- Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones.Molecular biology of the cell · 2013Article
- RNA-dependent regulation of the cell wall stress response.Nucleic acids research · 2012Article
- What makes the engine hum: Rad6, a cell cycle supercharger.Cell cycle (Georgetown, Tex.) · 2012Article
- Ergodic sets as cell phenotype of budding yeast cell cycle.PloS one · 2012Article
- An overview of Cdk1-controlled targets and processes.Cell division · 2010Article
- Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae.Sensors (Basel, Switzerland) · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saccharomyces cerevisiae must reach a carbon source-modulated critical cell size, protein content per cell at the onset of DNA replication (Ps), in order to enter S phase. Cells grown in glucose are larger than cells grown in ethanol. Here, we show that an increased level of the cyclin-dependent inhibitor Far1 increases cell size, whereas far1 Delta cells start bud emergence and DNA replication at a smaller size than wild type. Cln3 Delta, far1 Delta, and strains overexpressing Far1 do not delay budding during an ethanol glucose shift-up as wild type does. Together, these findings indicate that Cln3 has to overcome Far1 to trigger Cln-Cdc28 activation, which then turns on SBF- and MBF-dependent transcription. We show that a second threshold is required together with the Cln3/Far1 threshold for carbon source modulation of Ps. A new molecular network accounting for the setting of Ps is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.