ArticleThe Journal of cell biology2004
Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin.The Journal of cell biology · 2025Article
- Uptake of small extracellular vesicles by recipient cells is facilitated by paracrine adhesion signaling.Nature communications · 2025Article
- Engineering Nanofiber Scaffolds with Biomimetic Cues for Differentiation of Skin-Derived Neural Crest-like Stem Cells to Schwann Cells.International journal of molecular sciences · 2022Article
- Ligand-bound integrin αvβ6 internalisation and trafficking.Frontiers in cell and developmental biology · 2022Article
- Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease.Matrix biology plus · 2021Review
- The road best traveled: Neural crest migration upon the extracellular matrix.Seminars in cell & developmental biology · 2020Review
- Integrin trafficking in cells and tissues.Nature cell biology · 2019Review
- Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.Molecular cancer research : MCR · 2018Article
- Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells.Journal of cellular biochemistry · 2017Article
- Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis.Developmental biology · 2014Article
- Rab5 and Rab4 regulate axon elongation in the Xenopus visual system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Integrins and cAMP mediate netrin-induced growth cone collapse.Brain research · 2013Article
- Epithelial to mesenchymal transition: new and old insights from the classical neural crest model.Seminars in cancer biology · 2012Review
- What is bad in cancer is good in the embryo: importance of EMT in neural crest development.Seminars in cell & developmental biology · 2012Review
- Integrins as receptor targets for neurological disorders.Pharmacology & therapeutics · 2012Review
- Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons.PloS one · 2011Article
- Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration.Molecular & cellular proteomics : MCP · 2011Article
- The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics.Neuroscience · 2009Article
- Random versus directionally persistent cell migration.Nature reviews. Molecular cell biology · 2009Review
- Connexons and cell adhesion: a romantic phase.Histochemistry and cell biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell migration is essential for proper development of numerous structures derived from embryonic neural crest cells (NCCs). Although the migratory pathways of NCCs have been determined, the molecular mechanisms regulating NCC motility remain unclear. NCC migration is integrin dependent, and recent work has shown that surface expression levels of particular integrin alpha subunits are important determinants of NCC motility in vitro. Here, we provide evidence that rapid cranial NCC motility on laminin requires integrin recycling. NCCs showed both ligand- and receptor-specific integrin regulation in vitro. On laminin, NCCs accumulated internalized laminin but not fibronectin receptors over 20 min, whereas on fibronectin neither type of receptor accumulated internally beyond 2 min. Internalized laminin receptors colocalized with receptor recycling vesicles and were subsequently recycled back to the cell surface. Blocking receptor recycling with bafilomycin A inhibited NCC motility on laminin, indicating that substratum-dependent integrin recycling is essential for rapid cranial neural crest migration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.