ArticleBritish journal of pharmacology2004
Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Effect of pentoxifylline on serum levels and gene expression of inflammatory markers: a systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology · 2025Pooled it
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis.Molecular human reproduction · 2025Review
- Pentoxifylline in Dogs With Osteoarthritis: Comparative Treatment and Efficacy Analysis With Meloxicam.Veterinary medicine and science · 2025Article
- Ultrasound-assisted extraction, optimization, and purification of total flavonoids from Daphnegenkwa and analysis of their antioxidant, anti-inflammatory, and analgesic activities.Ultrasonics sonochemistry · 2024Article
- Brief research report: Repurposing pentoxifylline to treat intense acute swimming-Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms.Frontiers in pharmacology · 2022Article
- Analgesic Effect ofFrontiers in pharmacology · 2021Article
- A Hydroethanolic Leaf Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model.Inflammopharmacology · 2018Article
- Possible mechanisms involved in the anti-nociceptive effects of hydro-ethanolic leaf extract of Ziziphus abyssinica.Pharmaceutical biology · 2017Article
- Early inflammatory changes in radiation-induced oral mucositis : Effect of pentoxifylline in a mouse model.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Article
- Aryl-1,3,5-triazine ligands of histamine HInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Pharmacological studies on the anti-inflammatory and immunomodulatory role of pentoxifylline and its interaction with nitric oxide (NO) in experimental arthritis in rats.Inflammopharmacology · 2016Article
- Pentoxifylline reduces chronic post-ischaemia pain by alleviating microvascular dysfunction.European journal of pain (London, England) · 2014Article
- Drug repositioning: playing dirty to kill pain.CNS drugs · 2014Review
- Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis.Veterinary anaesthesia and analgesia · 2013Article
- Tetracyclines and pain.Naunyn-Schmiedeberg's archives of pharmacology · 2012Review
- Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Pentoxifylline decreases allodynia and hyperalgesia in a rat model of neuropathic pain.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2011Article
- Mesotherapy - The french connection.Journal of pharmacology & pharmacotherapeutics · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models. Pentoxifylline (0.5-1.6 mg kg(-1)) given 30 min before the stimulus significantly inhibited the writhing response induced by the intraperitoneal (i.p.) administration of either acetic acid (-90%) or zymosan (-83%), but not that of iloprost, in mice, as well as the zymosan-induced articular hyperalgesia in the zymosan arthritis in rats (-50%). Pentoxifylline also inhibited the mechanical hypernociception in rats induced by the intraplantar injection of either carrageenin (-81%), bradykinin (-56%) or tumor necrosis factor alpha (TNF-alpha; -46%), but not that induced by interleukin-1beta (IL-1beta) or prostaglandin E(2) (PGE(2)). Pentoxifylline did not inhibit the nociceptive response in the hot plate test in mice. Further, the antinociceptive effect of pentoxifylline in the writhing test in mice and the zymosan-induced articular hyperalgesia were not reversed by the coadministration of the opioid receptor antagonist naloxone. Thus, pentoxifylline antinociceptive effect is probably not mediated at a central level. Pentoxifylline significantly reduced TNF-alpha (-43%) and IL-1beta (-42%) concentrations in the joint exudates of rats stimulated by intra-articular injection of zymosan and the production of both cytokines (-66 and -86%, respectively) by mouse peritoneal macrophages stimulated in vivo with zymosan as well as the expression of TNF-alpha at the tissue level in carrageenin-injected rat paws. In conclusion, the antinociceptive activity of pentoxifylline is associated with the inhibition of the release of both TNF-alpha and IL-1beta.
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Registered trials
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