ReviewGrowth factors (Chur, Switzerland)2004
Brain-derived neurotrophic factor.
Review in Growth factors (Chur, Switzerland), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04954586 (Feasibility of Pain Informed Movement for People With Knee Osteoarthritis), which is not on this map. Cited by 615 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of Pain Informed Movement for People With Knee Osteoarthritis
Who cites it
615 citing papers in PubMed, 13 syntheses or guidelines pooled it, 1,468 citations in OpenAlex.
- Pooled it
- Association of Brain-derived Neurotrophic Factor Polymorphisms With Alcohol Use Disorder: An Updated Meta-Analysis of Genetic Association Studies.Brain and behavior · 2025Pooled it
- Effect of cannabis use on blood levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF): A systematic review and meta-analysis.Brain and behavior · 2024Pooled it
- Pooled it
- Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.Psychoneuroendocrinology · 2023Pooled it
- Brain-derived neurotrophic factor in diabetes mellitus: A systematic review and meta-analysis.PloS one · 2023Pooled it
- The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review.Cellular and molecular neurobiology · 2022Pooled it
- Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis.Journal of translational medicine · 2022Pooled it
- Prevalence of depression in patients with sarcopenia and correlation between the two diseases: systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2022Pooled it
- Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- A Critical Systematic Review of Current Evidence on the Effects of Physical Exercise on Whole/Regional Grey Matter Brain Volume in Populations at Risk of Neurodegeneration.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Pooled it
- Acute high-intensity interval training, but not reduced-exertion high-intensity interval training increase brain-derived neurotrophic factor in a block randomized controlled trial.Scientific reports · 2025Trial
- A multi-modal approach for the treatment of non-fluent/agrammatic variant of Primary Progressive Aphasia.Brain communications · 2025Trial
- Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial.European journal of nutrition · 2022Trial
- Molecular pathways underlying amyloid precursor protein-mediated regulation of adult-born neurons.Neural regeneration research · 2026Article
- Voluntary Exercise and Hippocampal Memory Enhancement: Decoding the Molecular Blueprint.Journal of molecular neuroscience : MN · 2026Review
- Exploring the Association of Polypharmacy and Depressive Symptoms with Sarcopenia in Older Adults.Journal of clinical medicine · 2026Article
- Exercise, Demethylase FTO, Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms.CNS neuroscience & therapeutics · 2026Review
555 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Since the purification of BDNF in 1982, a great deal of evidence has mounted for its central roles in brain development, physiology, and pathology. Aside from its importance in neural development and cell survival, BDNF appears essential to molecular mechanisms of synaptic plasticity. Basic activity-related changes in the central nervous system are thought to depend on BDNF modification of synaptic transmission, especially in the hippocampus and neocortex. Pathologic levels of BDNF-dependent synaptic plasticity may contribute to conditions such as epilepsy and chronic pain sensitization, whereas application of the trophic properties of BDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.