ArticleTransgenic research2004
Rederivation of transgenic and gene-targeted mice by embryo transfer.
Article in Transgenic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Eradication of Helicobacter spp. by using medicated diet in mice deficient in functional natural killer cells and complement factor D.Journal of the American Association for Laboratory Animal Science : JAALAS · 2010Trial
- Effective Eradication of Mouse Norovirus and Helicobacter spp. in Laboratory Mice (Mus musculus) via Iodine Immersion and Cross-Fostering Technique.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Article
- Cholinergic Control of GnRH Neuron Physiology and Luteinizing Hormone Secretion in Male Mice: Involvement of ACh/GABA Cotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Eliminating murine norovirus, Helicobacter hepaticus, and intestinal protozoa by embryo transfer for an entire mouse barrier facility.Experimental animals · 2022Article
- Successful pseudopregnancy of rats by short period artificial stimulation using sonic vibration.Scientific reports · 2022Article
- Specific Pathogen Free - A review of strategies in agriculture, aquaculture, and laboratory mammals and how they inform new recommendations for laboratory zebrafish.Research in veterinary science · 2021Review
- Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics.Brain structure & function · 2021Article
- Colony aging affects the reproductive performance of Swiss Webster females used as recipients for embryo transfer.Animal reproduction · 2020Article
- C57BL/6J and B6129F1 Embryo Transfer: Unilateral and Bilateral Transfer, Embryo Number and Recipient Female Background Control for the Optimization of Embryo Survival and Litter Size.Animals : an open access journal from MDPI · 2020Article
- Ivermectin-compounded Feed Compared with Topical Moxidectin-Imidacloprid for Eradication ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Results of Survey Regarding Prevalence of Adventitial Infections in Mice and Rats at Biomedical Research Facilities.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern.Transgenic research · 2016Article
- Use of Neonatal Fostering To Remove Helicobacter spp. from Deer Mice (Peromyscus maniculatus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Effects of medicated diet to eradicate Helicobacter spp. on growth, pathology, and infection status in Rag1-/- and nude mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Administration of luteinizing hormone releasing hormone agonist for synchronization of estrus and generation of pseudopregnancy for embryo transfer in rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2014Article
- Maternal antibodies or nonproductive infections confound the need for rederivation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- A technique for facile and precise transfer of mouse embryos.Avicenna journal of medical biotechnology · 2013Article
- The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer.Journal of the American Association for Laboratory Animal Science : JAALAS · 2010Article
- Effect of murine norovirus infection on mouse parvovirus infection.Journal of the American Association for Laboratory Animal Science : JAALAS · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on genetically engineered mice provides insights into the etiology, therapy, and genetic basis of human diseases. An important variable that affects the results of mouse studies is the health status of the animals. Pathogen burdens may confound observations and obscure underlying mechanisms. Mouse resource centers frequently rederive infected mouse strains. We review our experience on the use of a well-established technique, embryo transfer to rederive infected mouse strains. The following mouse pathogens were eliminated by embryo transfer: Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Rotavirus, Mouse Encephalomyelitis Virus, Mouse Adenovirus, Helicobacter species, endoparasites, and ectoparasites. We rederived transgenic mouse lines, gene-targeted mouse lines, and lines with spontaneous mutations. In the majority of strains, fertilized eggs for embryo transfer were obtained by mating superovulated egg donors with males of the desired genotype. A total of 309 embryo transfers were performed to rederive 96 mouse strains. The pregnancy rate was 76%; 1996 pups were born, of which 43% carried the desired genotype. We performed 44 additional embryo transfers to rederive 15 other strains. The pregnancy rate was lower (45%) and none of the 135 pups carried the desired genotype. Although we successfully eliminated the pathogens in all transfers, we were unable to obtain pups with the desired genotype in 15 of 111 mouse lines. Multiple factors affect the efficiency of rederivation by embryo transfer. They include the response to superovulation by embryo donors, the number and age of stud males, the yield of fertilized eggs, the number of embryo transfers, and genotyping.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.