ArticleEuropean journal of applied physiology2005
Norepinephrine as mediator in the stimulation of phagocytosis induced by moderate exercise.
Article in European journal of applied physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Acute exercise-induced catecholaminergic responses after 16 weeks of community-based exercise training in early-stage breast cancer survivors.World journal of clinical oncology · 2026Trial
- Renal denervation prevents long-term sequelae of ischemic renal injury.Kidney international · 2015Article
- Role of alpha- and beta-adrenoreceptors in rat monocyte/macrophage function at rest and acute exercise.Journal of physiology and biochemistry · 2014Article
- Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats.Journal of physiology and biochemistry · 2013Article
- A single session of intense exercise improves the inflammatory response in healthy sedentary women.Journal of physiology and biochemistry · 2011Article
- Virulence attenuation of Candida albicans genetic variants isolated from a patient with a recurrent bloodstream infection.PloS one · 2010Article
- Exercise-induced extracellular 72 kDa heat shock protein (Hsp72) stimulates neutrophil phagocytic and fungicidal capacities via TLR-2.European journal of applied physiology · 2010Article
- Role of phosphatidylinositol-3-kinase (PI3K), extracellular signal-regulated kinase (ERK) and nuclear transcription factor kappa beta (NF-k beta) on neutrophil phagocytic process of Candida albicans.Molecular and cellular biochemistry · 2010Article
- Effect of exercise on glutamine metabolism in macrophages of trained rats.European journal of applied physiology · 2009Article
- Norepinephrine-mediated suppression of phagocytosis by wound neutrophils.The Journal of surgical research · 2009Article
- Influence of gender and oral contraceptives intake on innate and inflammatory response. Role of neuroendocrine factors.Molecular and cellular biochemistry · 2008Article
- Role of Hsp72 and norepinephrine in the moderate exercise-induced stimulation of neutrophils' microbicide capacity.European journal of applied physiology · 2006Article
- Sympathoadrenal-dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat.British journal of pharmacology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During intensive exercise the stimulation of phagocytosis is mediated by "stress hormones". During moderate exercise, however, such mediation is less clear. The influence of moderate exercise (45 min at 55% maximal oxygen uptake) on the phagocytic capacity of neutrophils was evaluated in sedentary men. The exercise stimulated phagocytosis of Candida albicans, and the stimulation was maintained for at least 24 h. The possible neuroendocrine mediators were then investigated. Stimulation of phagocytosis was found after incubating neutrophils from sedentary individuals, who were in a basal state, with plasma from exercised individuals. Immediately after exercise, there was a significant increase in the concentration of norepinephrine, but not of epinephrine or cortisol. Incubation of neutrophils with this post-exercise physiological concentration of norepinephrine also stimulated phagocytosis, and the effect was blocked by both propranolol and phentolamine. The norepinephrine-augmented phagocytosis was accompanied by an increase in intracellular levels of cAMP, but not of cGMP or calcium. In conclusion, moderate exercise performed by sedentary people stimulates the phagocytic capacity of neutrophils, and the stimulation lasts for at least 24 h. Norepinephrine mediates the stimulation, although other mechanisms could be involved during the recovery period.
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