Evidence map›Paper›PMID 15517242›Full record

ArticleImmunogenetics2004

Polymorphism and conservation of the genes encoding Qa1 molecules.

Evan Hermel, Andrew J Hart, Irfan Gunduz, Hector Acton, Christina Kim, Mark Wurth, Samina Uddin, Caryn Smith, Kirsten Fischer Lindahl, Carla J Aldrich

Abstract read
PubMed Publisher
In one paragraph

Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. The murine MHC-E molecule Qa-1Frontiers in immunology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Evan HermelIndiana University School of Medicine, Evansville Center, 8600 University Blvd., Evansville, IN 47712-3534, USA.
Andrew J Hart
Irfan Gunduz
Hector Acton
Christina Kim
Mark Wurth
Samina Uddin
Caryn Smith
Kirsten Fischer Lindahl
Carla J Aldrich
University of Evansville · USIndiana University · USIndiana University School of MedicineHoward Hughes Medical Institute · USTouro University California · US

Funding

THE CLINTON COUNTY OUTREACH PROJECT (CCOP)P60DK020542 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CLARK, CHARLES MALCOLM · 1986 to 2003
$5.1M
STRUCTURE AND FUNCTION OF MHC CLASS IB HAPLOTYPESP01AI037818 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI FORMAN, JAMES M · 1995 to 2002
$1.9M
NIAID NIH HHS AI37818NIDDK NIH HHS P60 DK20542
6 · The paper itself

Abstract

To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1(a)-like and Qa1(b)-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

Indexed as

Conserved SequencePolymorphism, GeneticAmino Acid SequenceAnimalsHaplotypesHistocompatibility Antigens Class IMiceMolecular Sequence DataMultigene FamilyPhylogenyPolymerase Chain ReactionT-Lymphocytes, CytotoxicHistocompatibility Antigens Class IQ surface antigens

Identifiers

PMID15517242
OpenAlexW2050519980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.