ReviewOncogene2004
Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research.
Review in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- RNAi turns 25:contributions and challenges in insect science.Frontiers in insect science · 2023Review
- Article
- Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs.Cancer gene therapy · 2011Article
- Drosophila as a tool for personalized medicine: a primer.Personalized medicine · 2010Article
- Genomic screening with RNAi: results and challenges.Annual review of biochemistry · 2010Review
- siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells.Journal of experimental & clinical cancer research : CR · 2008Article
- Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes.Cancer gene therapy · 2006Article
- Minimizing off-target effects by using diced siRNAs for RNA interference.Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research · 2006Article
- In vivo and in vitro knockdown of FREP2 gene expression in the snail Biomphalaria glabrata using RNA interference.Developmental and comparative immunology · 2006Article
- RNAi in embryonic stem cells.Stem cell reviews · 2006Review
- CellProfiler: image analysis software for identifying and quantifying cell phenotypes.Genome biology · 2006Article
- RNA interference: from gene silencing to gene-specific therapeutics.Pharmacology & therapeutics · 2005Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The completion of whole-genome sequencing of various model organisms and the recent explosion of new technologies in the field of Functional Genomics and Proteomics is poised to revolutionize the way scientists identify and characterize gene function. One of the most significant advances in recent years has been the application of RNA interference (RNAi) as a means of assaying gene function. In the post-genomic era, advances in the field of cancer biology will rely upon the rapid identification and characterization of genes that regulate cell growth, proliferation, and apoptosis. Significant efforts are being directed towards cancer therapy and devising efficient means of selectively delivering drugs to cancerous cells. In this review, we discuss the promise of integrating genome-wide RNAi screens with proteomic approaches and small-molecule chemical genetic screens, towards improving our ability to understand and treat cancer.
Indexed as
Identifiers
15517017What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.