ArticleFamilial cancer2004
Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations.
Article in Familial cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 52 citations in OpenAlex.
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- Increased incidence of chronic lymphocytic leukaemia and lymphomas in patients with Merkel cell carcinoma - a population based study of 335 cases with neuroendocrine skin tumour.British journal of haematology · 2012Article
- Colorectal cancer in young patients in Israel: a distinct clinicopathological entity?World journal of surgery · 2010Article
- Differences in clinical and pathological characteristics of colorectal cancer in Arab as compared to Jewish patients in Northern Israel.Familial cancer · 2010Article
- A case-control study of levothyroxine and the risk of colorectal cancer.Journal of the National Cancer Institute · 2010Article
- Young-age onset of colorectal cancer in Israel.Techniques in coloproctology · 2009Article
- Article
- Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease?Cardiovascular diabetology · 2008Article
- Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.Annals of surgery · 2007Article
- Time trends of incidence of digestive system cancers in changle of China during 1988-2002.World journal of gastroenterology · 2006Article
- Rating the environmental and genetic risk factors for colorectal cancer.Journal of medicine and lifeArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAshkenazi Jews, as compared to non-European Jews and non-Jews, are at increased risk for colorectal cancer (CRC), this is attributed to genetic susceptibility and/or lifestyle.
aimsTo follow Israeli long-term trends in CRC incidence and mortality and their associations with ethnicity.
methodsAll Israeli CRC data accumulated 1970-2001 was used, age standardized rates (adjusted to world standard population) was computed by cancer site, US Surveillance, Epidemiology and End Results Program (SEER) Stage and ethnic group (continent of birth: Europe-America, Asia, Africa, Israel).
resultsFrom 1970, CRC incidence increased 190% in males and 140% in females; mainly colon cancer (270% and 185% respectively) (P < 0.01), while rectal cancer incidence decreased and is now stable. Stage 3 CRC increased while stage 4 decreased significantly (P < 0.01 for both). In 2001, CRC incidence per 100,000 in European-American-born males was 48.3, Asian and African born 35.5 and Israeli born 32.7 (relative risk (RR) 1.36, P = 0.03), while European-American female rates were 35 and all the others 26 (RR 1.35, P < 0.01). Overall survival increased 9% over 30 years (P < 0.01), 5 years survival since 1988-1996 for European-American born was 43.1%, Asian 46.7%, African 47.5% and Israeli 55.8%. Stage-2 CRC 5 years survivals for 1970-1996 (most had no post surgical treatment) for European-American born were 41.7%, Asian and African 44.8% and Israeli 53.4% (P < 0.05). Stage-3 CRC survivals (most received adjuvant therapy in addition to surgery) for European-American born was 38.8%, Asian and African 43.3% and Israeli 45.1% (P < 0.01).
conclusionsColon cancer has increased in Israel, mainly in males and European-American born. Israeli-born Jews (of 20 to 60% mixed ethnicity and lifestyle habits) have the lowest incidence and best survival data for stages-2 and -3 CRC. There is evidence of ethnic survival advantage and possibly in response to adjuvant oncological therapy.
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