ArticlePlant physiology2004
LIN, a Medicago truncatula gene required for nodule differentiation and persistence of rhizobial infections.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 94 citations in OpenAlex.
- A recently evolved Nodulin recruited by NIN for root hair rhizobial infection in Medicago truncatula.The New phytologist · 2026Article
- Article
- A legume cellulase required for rhizobial infection and colonization in root nodule symbiosis.Nature communications · 2025Article
- Single-nucleus transcriptomes reveal spatiotemporal symbiotic perception and early response in Medicago.Nature plants · 2023Article
- A Homeotic Mutation Changes Legume Nodule Ontogeny into Actinorhizal-Type Ontogeny.The Plant cell · 2020Article
- Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation.The Plant cell · 2020Review
- A protein complex required for polar growth of rhizobial infection threads.Nature communications · 2019Article
- Genome-wide DNA Methylation analysis in response to salinity in the model plant caliph medic (Medicago truncatula).BMC genomics · 2018Article
- Characterization of Novel Plant Symbiosis Mutants Using a New Multiple Gene-Expression ReporterFrontiers in plant science · 2018Article
- Gatekeeper Tyrosine Phosphorylation of SYMRK Is Essential for Synchronizing the Epidermal and Cortical Responses in Root Nodule Symbiosis.Plant physiology · 2016Article
- A Medicago truncatula Cystathionine-β-Synthase-like Domain-Containing Protein Is Required for Rhizobial Infection and Symbiotic Nitrogen Fixation.Plant physiology · 2016Article
- Identification and Expression Analysis of BURP Domain-Containing Genes in Medicago truncatula.Frontiers in plant science · 2016Article
- Comprehensive Comparative Genomic and Transcriptomic Analyses of the Legume Genes Controlling the Nodulation Process.Frontiers in plant science · 2016Article
- KNOTTED1-LIKE HOMEOBOX 3: a new regulator of symbiotic nodule development.Journal of experimental botany · 2015Article
- Remodeling of the infection chamber before infection thread formation reveals a two-step mechanism for rhizobial entry into the host legume root hair.Plant physiology · 2015Article
- The CCAAT box-binding transcription factor NF-YA1 controls rhizobial infection.Journal of experimental botany · 2014Article
- The identification of novel loci required for appropriate nodule development in Medicago truncatula.BMC plant biology · 2013Article
- Rhizobial infection is associated with the development of peripheral vasculature in nodules of Medicago truncatula.Plant physiology · 2013Article
- Genetic analysis of tolerance to boron toxicity in the legume Medicago truncatula.BMC plant biology · 2013Article
- Lotus japonicus E3 ligase SEVEN IN ABSENTIA4 destabilizes the symbiosis receptor-like kinase SYMRK and negatively regulates rhizobial infection.The Plant cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethyl methanesulfonate mutagenesis of the model legume Medicago truncatula has previously identified several genes required for early steps in nodulation. Here, we describe a new mutant that is defective in intermediate steps of nodule differentiation. The lin (lumpy infections) mutant is characterized by a 4-fold reduction in the number of infections, all of which arrest in the root epidermis, and by nodule primordia that initiate normally but fail to mature. Genetic analyses indicate that the symbiotic phenotype is conferred by a single gene that maps to the lower arm of linkage group 1. Transcriptional markers for early Nod factor responses (RIP1 and ENOD40) are induced in lin, as is another early nodulin, ENOD20, a gene expressed during the differentiation of nodule primordia. By contrast, other markers correlated with primordium differentiation (CCS52A), infection progression (MtN6), or nodule morphogenesis (ENOD2 and ENOD8) show reduced or no induction in homozygous lin individuals. Taken together, these results suggest that LIN functions in maintenance of rhizobial infections and differentiation of nodules from nodule primordia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.