ArticleThorax2004
Recovery of Burkholderia cenocepacia strain PHDC from cystic fibrosis patients in Europe.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Combination of Meropenem and Zinc Oxide Nanoparticles; Antimicrobial Synergism, Exaggerated Antibiofilm Activity, and Efficient Therapeutic Strategy against Bacterial Keratitis.Antibiotics (Basel, Switzerland) · 2022Article
- Precise measurement of the fitness effects of spontaneous mutations by droplet digital PCR in Burkholderia cenocepacia.Genetics · 2021Article
- Advances in Phage Therapy: Targeting theViruses · 2021Review
- Draft Genome of Burkholderia cenocepacia TAtl-371, a Strain from the Burkholderia cepacia Complex Retains Antagonism in Different Carbon and Nitrogen Sources.Current microbiology · 2019Article
- The Rate and Molecular Spectrum of Spontaneous Mutations in the GC-Rich Multichromosome Genome of Burkholderia cenocepacia.Genetics · 2015Article
- Lung transplantation for cystic fibrosis: results, indications, complications, and controversies.Seminars in respiratory and critical care medicine · 2015Review
- Comparative metabolic systems analysis of pathogenic Burkholderia.Journal of bacteriology · 2014Article
- Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Host evasion by Burkholderia cenocepacia.Frontiers in cellular and infection microbiology · 2011Review
- The changing microbial epidemiology in cystic fibrosis.Clinical microbiology reviews · 2010Review
- Biocide susceptibility of the Burkholderia cepacia complex.The Journal of antimicrobial chemotherapy · 2009Article
- The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.Journal of bacteriology · 2009Article
- Comparative genomics and an insect model rapidly identify novel virulence genes of Burkholderia mallei.Journal of bacteriology · 2008Article
- Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.Journal of clinical microbiology · 2008Article
- A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence.Infection and immunity · 2008Article
- Identification and characterisation of Pseudomonas 16S ribosomal DNA from ileal biopsies of children with Crohn's disease.PloS one · 2008Article
- Architecture of Burkholderia cepacia complex sigma70 gene family: evidence of alternative primary and clade-specific factors, and genomic instability.BMC genomics · 2007Article
- Revised approach for identification of isolates within the Burkholderia cepacia complex and description of clinical isolates not assigned to any of the known genomovars.Journal of clinical microbiology · 2007Article
- Environmental Burkholderia cepacia complex isolates in human infections.Emerging infectious diseases · 2007Article
- Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy.Journal of clinical microbiology · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurkholderia cenocepacia can cause life threatening respiratory tract infections in patients with cystic fibrosis (CF) and has a significant impact on survival. There is extensive evidence for patient to patient spread and nosocomial transmission of this organism, and several widespread B cenocepacia strains have been described including the transatlantic ET12 clone. A study was performed to compare B cenocepacia isolates recovered from CF patients receiving care in several European countries and strains isolated from other clinical samples and the environment, with reference isolates from the epidemic B cenocepacia strain PHDC which has so far only been recovered from CF patients and soil in the USA.
methodsA large collection of B cenocepacia isolates, including a large number recovered from CF patients receiving care in several European countries, Canada and the USA, were genotyped by means of randomly amplified polymorphic DNA typing (RAPD) and rep-PCR using the BOX-A1R primer (BOX-PCR).
resultsNineteen Burkholderia cenocepacia isolates cultured from clinical samples in Europe (18 recently recovered from CF patients in France and Italy and one recovered in 1964 from urine in the UK) showed RAPD fingerprinting patterns that were similar to patterns obtained from isolates of B cenocepacia strain PHDC. Subsequent analysis of these isolates using BOX-PCR confirmed that the European isolates and strain PHDC represent the same clone.
conclusionStrain PHDC represents a second transatlantic B cenocepacia clone capable of colonising patients with CF.
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