ArticleAmerican journal of human genetics2004
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- Association betweenJournal of genetics · 2019Pooled it
- Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population.Scientific reports · 2016Pooled it
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.Molecular psychiatry · 2006Trial
- Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.PloS one · 2025Article
- Specific Learning Disorders: Variation Analysis of 15 Candidate Genes in 9 Multiplex Families.Medicina (Kaunas, Lithuania) · 2023Article
- Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming.Behavioral and brain functions : BBF · 2023Article
- Rapid auditory processing and medial geniculate nucleus anomalies in Kiaa0319 knockout mice.Genes, brain, and behavior · 2022Article
- Dyslexia associated geneFrontiers in cell and developmental biology · 2022Article
- Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia.Molecular psychiatry · 2021Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione.International journal of molecular sciences · 2021Review
- Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.Translational psychiatry · 2019Article
- The Influence of Dyslexia Candidate Genes on Reading Skill in Old Age.Behavior genetics · 2018Article
- Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples.PloS one · 2018Article
- The role of READ1 and KIAA0319 genetic variations in developmental dyslexia: testing main and interactive effects.Journal of human genetics · 2017Article
- Article
- Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes.Behavior genetics · 2017Article
- Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment.Scientific reports · 2017Article
- Association analysis of dyslexia candidate genes in a Dutch longitudinal sample.European journal of human genetics : EJHG · 2017Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Several quantitative trait loci (QTLs) that influence developmental dyslexia (reading disability [RD]) have been mapped to chromosome regions by linkage analysis. The most consistently replicated area of linkage is on chromosome 6p23-21.3. We used association analysis in 223 siblings from the United Kingdom to identify an underlying QTL on 6p22.2. Our association study implicates a 77-kb region spanning the gene TTRAP and the first four exons of the neighboring uncharacterized gene KIAA0319. The region of association is also directly upstream of a third gene, THEM2. We found evidence of these associations in a second sample of siblings from the United Kingdom, as well as in an independent sample of twin-based sibships from Colorado. One main RD risk haplotype that has a frequency of approximately 12% was found in both the U.K. and U.S. samples. The haplotype is not distinguished by any protein-coding polymorphisms, and, therefore, the functional variation may relate to gene expression. The QTL influences a broad range of reading-related cognitive abilities but has no significant impact on general cognitive performance in these samples. In addition, the QTL effect may be largely limited to the severe range of reading disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.