ArticleBritish journal of pharmacology2004
Do low-affinity states of beta-adrenoceptors have roles in physiology and medicine?
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays.Handbook of experimental pharmacology · 2024Review
- Effect of selective β-adrenoceptor blockade and surgical resection of the celiac-superior mesenteric ganglion complex on delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human β1-adrenoceptor.Molecular pharmacology · 2014Article
- Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.Journal of medicinal chemistry · 2013Article
- Non-traditional roles of G protein-coupled receptors in basic cell biology.Molecular bioSystems · 2013Review
- Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor.PloS one · 2013Article
- Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.Journal of medicinal chemistry · 2011Article
- The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Challenges in β(3)-Adrenoceptor Agonist Drug Development.Therapeutic advances in endocrinology and metabolism · 2011Article
- A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors.PloS one · 2010Article
- The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors.British journal of pharmacology · 2010Article
- Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and beta2-adrenoceptor mechanisms.British journal of pharmacology · 2008Article
- Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells.BMC pharmacology · 2008Article
- Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.Trends in pharmacological sciences · 2007Review
- Pharmacological characterization of the beta-adrenoceptor that mediates the relaxant response to noradrenaline in guinea-pig tracheal smooth muscle.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
- beta-adrenoceptors and potassium channels.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
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1 author at 1 institution in 1 country.
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Abstract
The pharmacology once ascribed to the 'beta4-adrenoceptor' is now believed to be that of a low-affinity state of the beta1-adrenoceptor. The beta2-adrenoceptor may also have a low-affinity state or site, while the beta3-adrenoceptor--the original low-affinity beta-adrenoceptor--can display more than one pharmacology. In this issue, Mallem et al. show that CGP-12177 relaxes thoracic aorta rings from normal rats by stimulating vascular smooth muscle low-affinity beta1-adrenoceptors, apparently linked in part to Gi protein. By contrast, in rings from hypertensive rats, CGP-12177 acts mainly via endothelial beta3-adrenoceptors. This work raises the possibility that low-affinity states of beta-adrenoceptors have physiological roles, and suggests that they might be drug targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.