ArticleArteriosclerosis, thrombosis, and vascular biology2005
Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Atherosclerosis in Different Vascular Locations Unbiasedly Approached with Mouse Genetics.Genes · 2020Review
- Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans.International journal of obesity (2005) · 2017Article
- Mapping and Congenic Dissection of Genetic Loci Contributing to Hyperglycemia and Dyslipidemia in Mice.PloS one · 2016Article
- Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains.BMC genetics · 2015Article
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- Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.Circulation. Cardiovascular genetics · 2012Article
- Genetic basis of atherosclerosis: insights from mice and humans.Circulation research · 2012Review
- Sex-dimorphism in cardiac nutrigenomics: effect of trans fat and/or monosodium glutamate consumption.BMC genomics · 2011Article
- Metabolic syndrome components in murine models.Endocrine, metabolic & immune disorders drug targets · 2010Review
- Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- Differences in DBA/1J and DBA/2J reveal lipid QTL genes.Journal of lipid research · 2008Article
- Effects of in vitro maturation on gene expression in rhesus monkey oocytes.Physiological genomics · 2008Article
- Genetic and genomic insights into the molecular basis of atherosclerosis.Cell metabolism · 2007Review
- Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Identifying novel genes for atherosclerosis through mouse-human comparative genetics.American journal of human genetics · 2005Review
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe purpose of this study was to examine genetic factors responsible for metabolic syndrome and atherosclerosis in a setting of low-density lipoprotein (LDL) receptor deficiency in a cross between C57BL/6J (B6) and PERA/Ei (PERA) inbred mouse strains. METHODS AND
resultsComparison of metabolic phenotypes in B6 and PERA strains revealed the PERA genetic background to be dramatically more susceptible to hyperleptinemia, hyperglycemia, hypertriglyceridemia, elevated insulin levels, and body fat increase than the B6 background. To facilitate genetic analysis, metabolic syndrome-related traits and atherosclerotic lesion area were measured in 167 [(PERAxB6.129S7-Ldlr(tm1Her))xB6.129S7-Ldlr(tm1Her)]N2 male and female backcross mice that were homozygous for the Ldlr null allele. Quantitative trait locus analysis was performed using 153 polymorphic microsatellite markers spanning the genome. On chromosome 4, we identified a locus influencing plasma triglyceride, insulin, and leptin concentrations, body weight, and atherosclerosis. Several other genetic loci were identified with separate effects on plasma insulin, body weight, high-density lipoprotein cholesterol, and atherosclerosis.
conclusionsThe PERA strain is highly susceptible to the development of metabolic syndrome after feeding a Western-type diet. This susceptibility is due, in part, to a locus on murine chromosome 4 in which PERA alleles predispose to adiposity, increased insulin, and accelerated atherogenesis in the absence of marked hyperlipidemia.
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