ArticleGenetics2004
Epigenetic control of CACTA transposon mobility in Arabidopsis thaliana.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals.Genome biology · 2025Article
- The role of mobile DNA elements in the dynamics of plant genome plasticity.Journal of experimental botany · 2025Review
- Heat stress response and transposon control in plant shoot stem cells.Plant physiology · 2025Article
- Unravelling DNA methylation dynamics during developmental stages in Quercus ilex subsp. ballota [Desf.] Samp.BMC plant biology · 2024Article
- Identification of transcriptionally active transposons in Barley.BMC genomic data · 2023Article
- Arms race between anti-silencing and RdDM in noncoding regions of transposable elements.EMBO reports · 2023Article
- Fast co-evolution of anti-silencing systems shapes the invasiveness of Mu-like DNA transposons in eudicots.The EMBO journal · 2022Article
- RNA-directed DNA methylation prevents rapid and heritable reversal of transposon silencing under heat stress in Zea mays.PLoS genetics · 2021Article
- Article
- Silencing ofGenetics · 2020Article
- Centromere Repeats: Hidden Gems of the Genome.Genes · 2019Review
- The Role of Transposable Elements in Speciation.Genes · 2018Review
- Comparison of the Relative Potential for Epigenetic and Genetic Variation To Contribute to Trait Stability.G3 (Bethesda, Md.) · 2018Article
- Targeted DNA demethylation of theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Induction of epigenetic variation in Arabidopsis by over-expression of DNA METHYLTRANSFERASE1 (MET1).PloS one · 2018Article
- Creating Order from Chaos: Epigenome Dynamics in Plants with Complex Genomes.The Plant cell · 2016Review
- Epigenetics: Beyond Chromatin Modifications and Complex Genetic Regulation.Plant physiology · 2014Review
- Differential methylation during maize leaf growth targets developmentally regulated genes.Plant physiology · 2014Article
- Epiallelic variation in Arabidopsis thaliana.Cold Spring Harbor symposia on quantitative biology · 2012Review
- RNA-directed DNA methylation: mechanisms and functions.Plant signaling & behavior · 2010Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mutation, heritable developmental variation not based on a change in nucleotide sequence, is widely reported in plants. However, the developmental and evolutionary significance of such mutations remains enigmatic. On the basis of our studies of the endogenous Arabidopsis transposon CACTA, we propose that the inheritance of epigenetic gene silencing over generations can function as a transgenerational genome defense mechanism against deleterious movement of transposons. We previously reported that silent CACTA1 is mobilized by the DNA hypomethylation mutation ddm1 (decrease in DNA methylation). In this study, we report that CACTA activated by the ddm1 mutation remains mobile in the presence of the wild-type DDM1 gene, suggesting that de novo silencing is not efficient for the defense of the genome against CACTA movement. The defense depends on maintenance of transposon silencing over generations. In addition, we show that the activated CACTA1 element transposes throughout the genome in DDM1 plants, as reported previously for ddm1 backgrounds. Furthermore, the CACTA1 element integrated into both the ddm1-derived and the DDM1-derived chromosomal regions in the DDM1 wild-type plants, demonstrating that this class of transposons does not exhibit targeted integration into heterochromatin, despite its accumulation in the pericentromeric regions in natural populations. The possible contribution of natural selection as a mechanism for the accumulation of transposons and evolution of heterochromatin is discussed.
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