ArticleGenetics2004
Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 146 citations in OpenAlex.
- Pool-GWAS on reproductive dormancy in Drosophila simulans suggests a polygenic architecture.G3 (Bethesda, Md.) · 2022Article
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- Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.Molecular ecology · 2021Article
- Variation in sleep and metabolic function is associated with latitude and average temperature inEcology and evolution · 2018Article
- Genomic associations with bill length and disease reveal drift and selection across island bird populations.Evolution letters · 2018Article
- The Effect of Common Inversion PolymorphismsG3 (Bethesda, Md.) · 2017Article
- Gene expression and adaptive noncoding changes during human evolution.BMC genomics · 2017Article
- On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.Scientific reports · 2017Article
- Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.Nature ecology & evolution · 2017Article
- Adaptive dynamics of cuticular hydrocarbons in Drosophila.Journal of evolutionary biology · 2017Article
- Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments.Molecular biology and evolution · 2016Article
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- Parallel Evolution of Copy-Number Variation across Continents in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster.Molecular ecology · 2016Article
- Article
- Global Transcriptional Profiling of Diapause and Climatic Adaptation in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Comparative population genomics of latitudinal variation in Drosophila simulans and Drosophila melanogaster.Molecular ecology · 2016Article
- Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly.Journal of insect physiology · 2016Article
- Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We report a study in Drosophila melanogaster of latitudinal clines for 23 SNPs embedded in 13 genes (Pgi, Gapdh1, UGPase, Pglym78, Pglym87, Eno, Men, Gdh, Sod, Pgk, Mdh1, TreS, Treh) representing various metabolic enzymes. Our samples are from 10 populations spanning latitude from southern Florida to northern Vermont. Three new clines with latitude were detected. These are the amino acid polymorphisms in the NAD-dependent glutamate dehydrogenase (Gdh) and trehalase (Treh) genes, and a silent site polymorphism in the UDP-glucose pyrophosphorylase gene (UGPase). The result, when combined with the overall incidence and pattern of reports for six other genes (Adh, Gpdh, Pgm, G6pd, 6Pgd, Hex-C), presents a picture of latitudinal clines in metabolic genes prevalent around the branch point of competing pathways. For six of the seven amino acid polymorphisms showing significant latitudinal clines in North America, the derived allele is the one increasing with latitude, suggesting temperate adaptation. This is consistent with a model of an Afrotropical ancestral species adapting to temperate climates through selection favoring new mutations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.