ArticleGenetics2004
The gene Sex-lethal of the Sciaridae family (order Diptera, suborder Nematocera) and its phylogeny in dipteran insects.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Theme and variation in the evolution of insect sex determination.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Review
- Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).BMC genomics · 2019Article
- Article
- Article
- The comparative study of five sex-determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade.Development genes and evolution · 2015Article
- Biochemical and functional analysis of Drosophila-sciara chimeric sex-lethal proteins.PloS one · 2013Article
- Molecular and cytological characterization of repetitive DNA sequences from the centromeric heterochromatin of Sciara coprophila.Chromosoma · 2011Article
- The gene transformer-2 of Sciara (Diptera, Nematocera) and its effect on Drosophila sexual development.BMC developmental biology · 2011Article
- The transformer gene of Ceratitis capitata: a paradigm for a conserved epigenetic master regulator of sex determination in insects.Genetica · 2011Article
- Differential regulation drives plasticity in sex determination gene networks.BMC evolutionary biology · 2010Article
- The gene transformer-2 of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.BMC evolutionary biology · 2010Article
- Melav2, an elav-like gene, is essential for spermatid differentiation in the flatworm Macrostomum lignano.BMC developmental biology · 2009Article
- Two new chromodomain-containing proteins that associate with heterochromatin in Sciara coprophila chromosomes.Chromosoma · 2009Article
- The gene transformer of anastrepha fruit flies (Diptera, tephritidae) and its evolution in insects.PloS one · 2007Article
- The gene doublesex of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.Development genes and evolution · 2007Article
- Global analysis of X-chromosome dosage compensation.Journal of biology · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article reports the cloning and characterization of the gene homologous to Sex-lethal (Sxl) of Drosophila melanogaster from Sciara coprophila, Rhynchosciara americana, and Trichosia pubescens. This gene plays the key role in controlling sex determination and dosage compensation in D. melanogaster. The Sxl gene of the three species studied produces a single transcript encoding a single protein in both males and females. Comparison of the Sxl proteins of these Nematocera insects with those of the Brachycera showed their two RNA-binding domains (RBD) to be highly conserved, whereas significant variation was observed in both the N- and C-terminal domains. The great majority of nucleotide changes in the RBDs were synonymous, indicating that purifying selection is acting on them. In both sexes of the three Nematocera insects, the Sxl protein colocalized with transcription-active regions dependent on RNA polymerase II but not on RNA polymerase I. Together, these results indicate that Sxl does not appear to play a discriminatory role in the control of sex determination and dosage compensation in nematocerans. Thus, in the phylogenetic lineage that gave rise to the drosophilids, evolution coopted for the Sxl gene, modified it, and converted it into the key gene controlling sex determination and dosage compensation. At the same time, however, certain properties of the recruited ancestral Sxl gene were beneficial, and these are maintained in the evolved Sxl gene, allowing it to exert its sex-determining and dose compensation functions in Drosophila.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.