ArticleGenetics2004
Drosophila damaged DNA-binding protein 1 is an essential factor for development.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
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- Obesity impairs gut repair via AFABP-mediated iron overload in intestinal stem cells.Nature metabolism · 2026Article
- NSD Overexpression in the Fat Body Increases Antimicrobial Peptide Production by the Immune Deficiency Pathway inInternational journal of molecular sciences · 2023Article
- CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation.PLoS biology · 2019Article
- Loci associated with skin pigmentation identified in African populations.Science (New York, N.Y.) · 2017Article
- Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth.The Journal of biological chemistry · 2016Article
- Control of apoptosis by Drosophila DCAF12.Developmental biology · 2016Article
- Article
- Altering the sex determination pathway in Drosophila fat body modifies sex-specific stress responses.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven.Cell cycle (Georgetown, Tex.) · 2011Article
- A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.Science signaling · 2011Article
- Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Molecular biology of the cell · 2010Article
- An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis.BMC developmental biology · 2010Article
- A Drosophila insulin-like peptide promotes growth during nonfeeding states.Developmental cell · 2009Article
- Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance.Plant molecular biology · 2009Article
- Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.Molecular and cellular biology · 2008Article
- TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster.Molecular and cellular biology · 2008Article
- Functional characterization of the putative Aspergillus nidulans DNA damage binding protein homologue DdbA.Molecular genetics and genomics : MGG · 2008Article
- DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility.Molecular and cellular biology · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The damaged DNA-binding protein (DDB) complex, thought to recognize (6-4) photoproducts and other lesions in DNA, has been implicated to have a role in global genomic nucleotide excision repair (NER) and E2F-1-mediated transcription. The complex consists of a heterodimer of p127 (DDB1) and p48 (DDB2), the latter also being known as XPE. We reported previously that in Drosophila expression of the DDB1 (D-DDB1) gene is controlled by the DRE/DREF system, and external injury to DNA is not essential for D-DDB1 function. In the present study of the function of D-DDB1 in a multicellular system, we prepared transgenic flies, which were knocked down for the D-DDB1 gene due to RNA interference (RNAi), and performed immunocytochemistry to ascertain the distribution of D-DDB1 in the eye imaginal disc. It was found to be abundant in the anterior of the morphogenetic furrow (MF). Whole-body overexpression of dsRNA of D-DDB1 in Drosophila using a GAL4-UAS targeted expression system induced melanotic tumors and caused complete lethality. When limited to the eye imaginal disc, a severe rough eye phenotype resulted. Correspondingly, all of the D-DDB1 gene knocked-out flies also died. D-DDB1 therefore appears to be an essential development-associated factor in a multicellular organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.