ArticleGenetics2004
Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Regulatory and metabolic control of microbial biosynthetic gene clusters.Communications biology · 2026Review
- Genetic dissection of the degradation pathways for the mycotoxin fusaric acid inApplied and environmental microbiology · 2023Article
- The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi.Molecules (Basel, Switzerland) · 2023Review
- Regulation of the Leucine Metabolism inJournal of fungi (Basel, Switzerland) · 2022Article
- EngineeringJournal of fungi (Basel, Switzerland) · 2021Article
- Transcriptome Analyses ofG3 (Bethesda, Md.) · 2020Article
- A common approach for absolute quantification of short chain CoA thioesters in prokaryotic and eukaryotic microbes.Microbial cell factories · 2020Article
- Propionate metabolism in a human pathogenic fungus: proteomic and biochemical analyses.IMA fungus · 2020Article
- Article
- Differential Metabolism of a Two-Carbon Substrate by Members of theFrontiers in microbiology · 2017Article
- Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans.BMC genomics · 2016Article
- Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.Scientific reports · 2015Article
- Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism.Applied and environmental microbiology · 2015Article
- Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA.The Journal of biological chemistry · 2014Article
- The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii.Molecular microbiology · 2013Article
- Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism.BMC biochemistry · 2010Article
- ATP-citrate lyase is required for production of cytosolic acetyl coenzyme A and development in Aspergillus nidulans.Eukaryotic cell · 2010Article
- Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae.Eukaryotic cell · 2009Article
- Generation and phenotypic characterization of Aspergillus nidulans methylisocitrate lyase deletion mutants: methylisocitrate inhibits growth and conidiation.Applied and environmental microbiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propionyl-CoA is an intermediate metabolite produced through a variety of pathways including thioesterification of propionate and catabolism of odd chain fatty acids and select amino acids. Previously, we found that disruption of the methylcitrate synthase gene, mcsA, which blocks propionyl-CoA utilization, as well as growth on propionate impaired production of several polyketides-molecules typically derived from acetyl-CoA and malonyl-CoA-including sterigmatocystin (ST), a potent carcinogen, and the conidiospore pigment. Here we describe three lines of evidence that demonstrate that excessive propionyl-CoA levels in the cell can inhibit polyketide synthesis. First, inactivation of a putative propionyl-CoA synthase, PcsA, which converts propionate to propionyl-CoA, restored polyketide production and reduced cellular propionyl-CoA content in a DeltamcsA background. Second, inactivation of the acetyl-CoA synthase, FacA, which is also involved in propionate utilization, restored polyketide production in the DeltamcsA background. Third, fungal growth on several compounds (e.g., heptadecanoic acid, isoleucine, and methionine) whose catabolism includes the formation of propionyl-CoA, were found to inhibit ST and conidiospore pigment production. These results demonstrate that excessive propionyl-CoA levels in the cell can inhibit polyketide synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.