ArticleProceedings of the National Academy of Sciences of the United States of America2004
Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Frizzled1 and Frizzled2 are not redundant for competitive survival under low-Wingless levels in the developingOpen biology · 2025Article
- Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.The Journal of biological chemistry · 2018Article
- Review
- Assembly and architecture of the Wnt/β-catenin signalosome at the membrane.British journal of pharmacology · 2017Review
- Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain.Oncotarget · 2017Article
- Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.Genes & development · 2017Article
- G protein-coupled receptors: the evolution of structural insight.AIMS biophysics · 2017Article
- Wnt Signaling: Role in Regulation of Haematopoiesis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Review
- Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.BMC biology · 2014Article
- Wingless/Wnt signaling in Drosophila: the pattern and the pathway.Molecular reproduction and development · 2013Review
- Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila.Nature cell biology · 2013Article
- Article
- The complex world of WNT receptor signalling.Nature reviews. Molecular cell biology · 2012Review
- A quest for the mechanism regulating global planar cell polarity of tissues.Trends in cell biology · 2009Review
- Myocilin is a modulator of Wnt signaling.Molecular and cellular biology · 2009Article
- Planar cell polarity: A bridge too far?Current biology : CB · 2008Article
- The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling.Developmental cell · 2008Article
- The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate.Neural development · 2008Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the Frizzled family of serpentine transmembrane receptors are required to transduce Wingless/Int (Wnt) signals and contain in their N-terminal regions a conserved Wnt-binding cysteine-rich domain (CRD). Each CRD has specific affinities for particular Wnts, and it is generally believed that signal transduction depends on the strength of this interaction. Here, we report in vivo evidence that the CRD is dispensable for Frizzled family receptors to transduce Wingless (Wg), the primary Wnt signal in Drosophila. Thus, we infer that signal transduction does not require binding of Wg to the CRD, but instead depends on interactions between Wg and other portions of the receptor, or other proteins of the receptor complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.