ArticleThe Journal of physiology2005
Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Interleukin-22 receptor 1-mediated stimulation of T-type CaCell communication and signaling : CCS · 2024Article
- Long-term depression-inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function.Nature communications · 2021Article
- Inhibition promotes long-term potentiation at cerebellar excitatory synapses.Scientific reports · 2016Article
- Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.The Journal of physiology · 2016Article
- Ontogenic Changes and Differential Localization of T-type Ca(2+) Channel Subunits Cav3.1 and Cav3.2 in Mouse Hippocampus and Cerebellum.Frontiers in neuroanatomy · 2016Article
- Differential CaMKII regulation by voltage-gated calcium channels in the striatum.Molecular and cellular neurosciences · 2015Article
- T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Signal processing by T-type calcium channel interactions in the cerebellum.Frontiers in cellular neuroscience · 2013Review
- The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures.Neural plasticity · 2013Article
- Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons.Cerebellum (London, England) · 2012Review
- Calcium signaling in dendritic spines.Cold Spring Harbor perspectives in biology · 2012Article
- Electrical advantages of dendritic spines.PloS one · 2012Article
- Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Dendritic calcium channels and their activation by synaptic signals in auditory coincidence detector neurons.Journal of neurophysiology · 2009Article
- Ca(2+) signaling by T-type Ca(2+) channels in neurons.Pflugers Archiv : European journal of physiology · 2009Review
- Channeling studies in yeast: yeast as a model for channelopathies?Neuromolecular medicine · 2006Review
- Entrainment of cerebellar Purkinje cell spiking activity using pulsed ultrasound stimulation.Brain stimulationArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functional role of low voltage activated (LVA) calcium channels in the cerebellar Purkinje cell dendritic tree is not completely understood. Since the localization of these channels will influence their possible roles in dendritic integration and induction of plasticity, we set out to characterize the LVA calcium current in Purkinje cell dendrites in acute cerebellar slices of young rats. Using a combination of electrophysiological recordings and two-photon laser scanning microscopy, we show that LVA calcium current recorded at the soma can be correlated with voltage-dependent calcium transients in Purkinje cell dendritic spines. Blocking sodium and potassium conductances allowed us to isolate and characterize a fast inactivating inward current activated positive to -55 mV. Activation and steady-state inactivation kinetics, voltage-dependent deactivation kinetics, and pharmacological experiments (using omega-agatoxin-IVA, mibefradil and nickel) show that this current is carried by T-type calcium channels. Furthermore, the LVA calcium transient observed in the dendritic spines of the Purkinje cell is well correlated with the current recorded at the soma, suggesting that T-type calcium channels are the main component of the LVA calcium input in spines. The fast rising phase of the calcium transient in spines and the absence of delay between the onset in the spine and the parent dendrite show that T-type calcium channels are present both in spines and dendrites of the Purkinje cell.
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