ArticleMolecular and cellular biology2004
In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Elongin B orchestrates chromatin and transcriptional programs in H3K27M-mutant diffuse midline glioma.bioRxiv : the preprint server for biology · 2026Article
- A genetic screen for regulators of Drosophila histone H1 binding and chromosome structure in vivo.Genetics · 2026Article
- TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer.OncoTargets and therapy · 2021Article
- The hunt for RNA polymerase II elongation factors: a historical perspective.Nature structural & molecular biology · 2019Review
- Def1 interacts with TFIIH and modulates RNA polymerase II transcription.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses.The Journal of biological chemistry · 2015Article
- A novel approach for studying histone H1 function in vivo.Genetics · 2015Article
- Maize Elongin C interacts with the viral genome-linked protein, VPg, of Sugarcane mosaic virus and facilitates virus infection.The New phytologist · 2014Article
- Transcriptional properties of mammalian elongin A and its role in stress response.The Journal of biological chemistry · 2013Article
- Transcriptional elongation checkpoint control in development and disease.Genes & development · 2013Review
- The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings.PloS one · 2013Article
- The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo.PLoS genetics · 2012Article
- Elongin C is a mediator of Notch4 activity in human renal tubule cells.Biochimica et biophysica acta · 2011Article
- Drosophila ISWI regulates the association of histone H1 with interphase chromosomes in vivo.Genetics · 2009Article
- Spt6 enhances the elongation rate of RNA polymerase II in vivo.The EMBO journal · 2009Article
- Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment.Molecular genetics and genomics : MGG · 2007Article
- Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Transcription elongation factor S-II is required for definitive hematopoiesis.Molecular and cellular biology · 2006Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
A number of transcription factors that increase the catalytic rate of mRNA synthesis by RNA polymerase II (Pol II) have been purified from higher eukaryotes. Among these are the ELL family, DSIF, and the heterotrimeric elongin complex. Elongin A, the largest subunit of the elongin complex, is the transcriptionally active subunit, while the smaller elongin B and C subunits appear to act as regulatory subunits. While much is known about the in vitro properties of elongin A and other members of this class of elongation factors, the physiological role(s) of these proteins remain largely unclear. To elucidate in vivo functions of elongin A, we have characterized its Drosophila homologue (dEloA). dEloA associates with transcriptionally active puff sites within Drosophila polytene chromosomes and exhibits many of the expected biochemical and cytological properties consistent with a Pol II-associated elongation factor. RNA interference-mediated depletion of dEloA demonstrated that elongin A is an essential factor that is required for proper metamorphosis. Consistent with this observation, dEloA expression peaks during the larval stages of development, suggesting that this factor may be important for proper regulation of developmental events during these stages. The discovery of the role of elongin A in an in vivo model system defines the novel contribution played by RNA polymerase II elongation machinery in regulation of gene expression that is required for proper development.
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