ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Intrinsic noise in cultured hippocampal neurons: experiment and modeling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed.
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- Biological neurons act as generalization filters in reservoir computing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- How to correctly quantify neuronal phase-response curves from noisy recordings.Journal of computational neuroscience · 2019Article
- Data-driven inference for stationary jump-diffusion processes with application to membrane voltage fluctuations in pyramidal neurons.Journal of mathematical neuroscience · 2019Article
- Gap junctions set the speed and nucleation rate of stage I retinal waves.PLoS computational biology · 2019Article
- The Impact of Frequency Scale on the Response Sensitivity and Reliability of Cortical Neurons to 1/fFrontiers in cellular neuroscience · 2019Article
- Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction.Cell death & disease · 2015Article
- Power laws from linear neuronal cable theory: power spectral densities of the soma potential, soma membrane current and single-neuron contribution to the EEG.PLoS computational biology · 2014Article
- Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise.Frontiers in computational neuroscience · 2014Article
- Firing rate and pattern heterogeneity in the globus pallidus arise from a single neuronal population.Journal of neurophysiology · 2013Article
- Spontaneous olfactory receptor neuron activity determines follower cell response properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity.Frontiers in computational neuroscience · 2012Article
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3 authors.
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Abstract
Ion channels open and close stochastically. The fluctuation of these channels represents an intrinsic source of noise that affects the input-output properties of the neuron. We combined whole-cell measurements with biophysical modeling to characterize the intrinsic stochastic and electrical properties of single neurons as observed at the soma. We measured current and voltage noise in 18 d postembryonic cultured neurons from the rat hippocampus, at various subthreshold and near-threshold holding potentials in the presence of synaptic blockers. The observed current noise increased with depolarization, as ion channels were activated, and its spectrum demonstrated generalized 1/f behavior. Exposure to TTX removed a significant contribution from Na+ channels to the noise spectrum, particularly at depolarized potentials, and the resulting spectrum was now dominated by a single Lorentzian (1/f2) component. By replacing the intracellular K+ with Cs+, we demonstrated that a major portion of the observed noise was attributable to K+ channels. We compared the measured power spectral densities to a 1-D cable model of channel fluctuations based on Markov kinetics. We found that a somatic compartment, in combination with a single equivalent cylinder, described the effective geometry from the viewpoint of the soma. Four distinct channel populations were distributed in the membrane and modeled as Lorentzian current noise sources. Using the NEURON simulation program, we summed up the contributions from the spatially distributed current noise sources and calculated the total voltage and current noise. Our quantitative model reproduces important voltage- and frequency-dependent features of the data, accounting for the 1/f behavior, as well as the effects of various blockers.
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