ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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Who cites it
54 citing papers in PubMed, 88 citations in OpenAlex.
- Pharmacological Relevance of β-, γ-, and LINGO Auxiliary Subunits in BK Channel Modulation.ChemMedChem · 2026Review
- Compensatory Interplay Between Clarin-1 and Clarin-2 Deafness-Associated Proteins Governs Phenotypic Variability in Hearing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss.The Journal of clinical investigation · 2025Article
- The mechanism of CaThe Journal of biological chemistry · 2025Article
- In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells.JCI insight · 2024Article
- Nuclear Translocation Triggered at the Onset of Hearing in Cochlear Inner Hair Cells of Rats and Mice.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- CaInternational journal of molecular sciences · 2023Review
- Preparation of the intact rodent organ of Corti for RNAscope and immunolabeling, confocal microscopy, and quantitative analysis.STAR protocols · 2021Article
- Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea.The Journal of physiology · 2021Article
- Synaptic Release Potentiation at Aging Auditory Ribbon Synapses.Frontiers in aging neuroscience · 2021Article
- Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea.The Journal of physiology · 2020Article
- Altered cochlear innervation in developing and mature naked and Damaraland mole rats.The Journal of comparative neurology · 2019Article
- LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Differential Expression of CaExperimental neurobiology · 2018Article
- Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.Scientific reports · 2018Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Different CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- BK channel inactivation gates daytime excitability in the circadian clock.Nature communications · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Auditory hair cells from nonmammalian vertebrates are electrically tuned to specific sound frequencies primarily by the interactions of voltage-gated calcium channels and calcium-activated potassium (BK) channels colocalized at synaptic active zones. Mammalian inner hair cells are not electrically tuned and, yet, BK channels are also thought to reside at active zones. Using patch-clamp recordings and immunofluorescence, we characterized BK channel expression in mouse inner hair cells. Unexpectedly, these channels have inactivating currents and are clustered near the apex of the cell away from synaptic sites near the base. These results indicate a novel function of BK channels in mammalian inner hair cells and provide a framework for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.