ArticleMolecular biology of the cell2005
Critical role of collapsin response mediator protein-associated molecule CRAM for filopodia and growth cone development in neurons.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- An update on optic neuritis.Journal of neurology · 2023Article
- Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release.International journal of molecular sciences · 2023Article
- Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders.Frontiers in neuroscience · 2023Review
- CRMP5 Antibodies-Diagnostic Challenges.Frontiers in neurology · 2021Article
- Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration.Frontiers in cellular neuroscience · 2020Article
- Collapsin Response Mediator Proteins: Novel Targets for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Review
- miR-214-5p inhibits human prostate cancer proliferation and migration through regulating CRMP5.Cancer biomarkers : section A of Disease markers · 2019Article
- Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.Cellular and molecular life sciences : CMLS · 2018Article
- DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.Cancer medicine · 2017Article
- (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.Molecular neurobiology · 2016Article
- CRMP‑5 interacts with actin to regulate neurite outgrowth.Molecular medicine reports · 2016Article
- Collapsin Response Mediator Protein-1 Regulates Arp2/3-dependent Actin Assembly.The Journal of biological chemistry · 2016Article
- Article
- Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review).Oncology letters · 2014Article
- Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.The Journal of biological chemistry · 2014Article
- CRMP-5 interacts with tubulin to promote growth cone development in neurons.International journal of clinical and experimental medicine · 2014Article
- Collapsin response mediator proteins regulate neuronal development and plasticity by switching their phosphorylation status.Molecular neurobiology · 2012Review
- CRMP5-associated GTPase (CRAG) protein protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos-dependent activator protein-1 activation.The Journal of biological chemistry · 2011Article
- CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- CRMP5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse brain.PloS one · 2011Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collapsin response mediator proteins (CRMPs) have been implicated in signaling of axonal guidance, including semaphorins. We have previously identified a unique member of this gene family, CRMP-associated molecule CRAM (CRMP-5), which is phylogenetically divergent from the other four CRMPs. In this study, we have examined the distribution and function of CRAM in developing neurons. Immunohistochemical analysis showed accumulation of CRAM in the filopodia of growth cones. Experiments using cytochalasin D indicated that filopodial localization of CRAM was independent of filamentous actin. Overexpression of CRAM in neuronal cells significantly promoted filopodial growth and led to the formation of supernumerary growth cones, which acquired resistance to semaphorin-3A stimulation. Finally, knockdown of CRAM by using RNA interference blocked filopodial formation and revealed an aberrant morphology of growth cones. We propose that CRAM regulates filopodial dynamics and growth cone development, thereby restricting the response of growth cone to repulsive guidance cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.