ArticleMolecular biology of the cell1992
Bone morphogenetic proteins-2 and -4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cells.
Article in Molecular biology of the cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 71 citations in OpenAlex.
- Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells.Journal of cellular biochemistry · 2016Article
- Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.Journal of cellular biochemistry · 2015Review
- Bidirectional, optical sign-dependent regulation of BMP2 gene expression in chick retinal pigment epithelium.Investigative ophthalmology & visual science · 2012Article
- An in vivo map of bone morphogenetic protein 2 post-transcriptional repression in the heart.Genesis (New York, N.Y. : 2000) · 2011Article
- Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells.Diabetes · 2010Article
- The Yin and Yang of bone morphogenetic proteins in cancer.Cytokine & growth factor reviews · 2010Review
- Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.PloS one · 2010Article
- Repressive BMP2 gene regulatory elements near the BMP2 promoter.Biochemical and biophysical research communications · 2010Article
- Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors.Gene · 2007Article
- Retinoic acid regulation of eye and testis-specific transcripts within a complex locus.Mechanisms of development · 2007Article
- An autopsy case of malignant mesothelioma with osseous and cartilaginous differentiation: bone morphogenetic protein-2 in mesothelial cells and its tumor.Digestive diseases and sciences · 1999Article
- Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.Molecular and cellular biology · 1995Article
- Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bone morphogenetic proteins-2 and -4 (BMPs-2 and -4) are transforming growth factor beta-related proteins that can induce bone formation in vivo. We observed that the level of endogenous BMP-2 mRNA increased an average of 11-fold on differentiation of F9 embryonal carcinoma cells into parietal endoderm after treatment with retinoic acid (RA) and cAMP, whereas the message for the closely related BMP-4 decreased 12-fold after this treatment. Therefore, the effects of exogenous recombinant BMP-2 protein on the RA-induced differentiation of F9 embryonal carcinoma cells were investigated. BMP-2 addition altered the growth and morphology of RA-treated but not untreated cells. Moreover, the abundance of several messages was affected by exogenous BMP-2 treatment. Notably, the BMP-2 and -4 messages themselves were reduced by the addition of exogenous BMP-2. The observations suggest that RA, which is known to affect bone morphogenesis, may regulate the osteoinductive proteins, BMP-2 and -4. Furthermore, BMP-2 and -4 may be involved in preimplantation embryogenesis.
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