SynthesisRespiratory research2004
Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review.
Synthesis in Respiratory research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Neuropsychiatric events associated with montelukast in patients with asthma: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Budesonide/formoterol maintenance and reliever therapy in primary care asthma management: effects on bronchial hyperresponsiveness and asthma control.Primary care respiratory journal : journal of the General Practice Airways Group · 2012Trial
- Smoking and Lung Function Response to Inhaled Glucocorticoids in Adult-Onset Asthma.Journal of asthma and allergy · 2026Article
- Expert opinion on gray areas in asthma management: A lesson from the innovative project "revolution in asthma" of the Italian thoracic society (AIPO-ITS).Clinical and translational allergy · 2025Review
- Review
- Effects of theophylline combined with inhaled corticosteroids on patients with moderate and severe asthma and changes of T lymphocyte subsets in peripheral blood.Central-European journal of immunology · 2023Article
- Defined daily dose definition in medication adherence assessment in asthma.European clinical respiratory journal · 2023Article
- Inhaled corticosteroid dose is associated withBMJ open respiratory research · 2021Article
- Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics.Journal of asthma and allergy · 2021Article
- Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications.The Korean journal of internal medicine · 2020Review
- Severe Asthma-Perspectives From Adult and Pediatric Pulmonology.Frontiers in pediatrics · 2019Review
- Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms.Mediators of inflammation · 2016Review
- Seinäjoki Adult Asthma Study (SAAS): a protocol for a 12-year real-life follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialised care.NPJ primary care respiratory medicine · 2015Article
- Diagnosis and pharmacotherapy of stable chronic obstructive pulmonary disease: the finnish guidelines.Basic & clinical pharmacology & toxicology · 2015Review
- The Saudi initiative for asthma - 2012 update: Guidelines for the diagnosis and management of asthma in adults and children.Annals of thoracic medicine · 2012Article
- Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.American journal of respiratory cell and molecular biology · 2011Article
- Sleep disorders in patients with bronchial asthma.Materia socio-medica · 2011Article
- Inhaled Corticosteroids.Pharmaceuticals (Basel, Switzerland) · 2010Review
- The Saudi Initiative for Asthma.Annals of thoracic medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medline/PubMed to identify randomised and blinded trials. To demonstrate the benefit that can be obtained by increasing the dose of ICS, dose-response studies with at least three different ICS doses were identified. To demonstrate whether more benefit can be obtained by adding long-acting beta2-agonist (LABA), leukotriene antagonist (LTRA) or theophylline than by increasing the dose of ICS, studies comparing these options were identified. Thirdly, studies comparing the different "add-on" options were identified. The addition of a LABA is more effective than increasing the dose of ICS in improving asthma control. By increasing the dose of ICS, clinical improvement is likely to be of small magnitude. Addition of a LTRA or theophylline to the treatment regimen appears to be equivalent to doubling the dose of ICS. Addition of a LABA seems to be superior to an LTRA in improving lung function. However, addition of LABA and LTRA may be equal with respect to asthma exacerbations. However, more and longer studies are needed to better clarify the role of LTRAs and theophylline as add-on therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.