ArticleJournal of virology2004
A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Myeloid cell tropism enables MHC-E-restricted CD8Science immunology · 2022Article
- Review
- A novel strain of cynomolgus macaque cytomegalovirus: implications for host-virus co-evolution.BMC genomics · 2016Article
- Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network.Trends in microbiology · 2015Review
- The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.Journal of molecular biology · 2013Review
- Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies.Translational research : the journal of laboratory and clinical medicine · 2013Review
- Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication.PLoS pathogens · 2013Article
- Reevaluation of the coding potential and proteomic analysis of the BAC-derived rhesus cytomegalovirus strain 68-1.Journal of virology · 2012Article
- Genomic sequencing and characterization of cynomolgus macaque cytomegalovirus.Journal of virology · 2011Article
- Human cytomegalovirus US7 is regulated synergistically by two virally encoded microRNAs and by two distinct mechanisms.Journal of virology · 2011Article
- Herpesvirus BACs: past, present, and future.Journal of biomedicine & biotechnology · 2011Review
- RCMV increases intimal hyperplasia by inducing inflammation, MCP-1 expression and recruitment of adventitial cells to intima.Herpesviridae · 2010Article
- A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs.PLoS pathogens · 2010Article
- Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas.Journal of virology · 2010Article
- Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes.Virology · 2009Article
- A novel Cre recombinase imaging system for tracking lymphotropic virus infection in vivo.PloS one · 2009Article
- Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.Nature medicine · 2009Article
- Efficient replication of rhesus cytomegalovirus variants in multiple rhesus and human cell types.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Inhibition of cyclooxygenase activity blocks cell-to-cell spread of human cytomegalovirus.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Passive immunization reduces murine cytomegalovirus-induced brain pathology in newborn mice.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostaglandins from arachidonic acid. The eicosanoids function as critical regulators of a number of cellular processes, including the acute and chronic inflammatory response, hemostasis, and the innate immune response. Human cytomegalovirus (HCMV), which does not encode a viral COX-2 isoform, has been shown to induce cellular COX-2 expression. Importantly, although the precise role of COX-2 in CMV replication is unknown, COX-2 induction was shown to be critical for normal HCMV replication. In an earlier study, we identified an open reading frame (Rh10) within the rhesus cytomegalovirus (RhCMV) genome that encoded a putative protein (designated vCOX-2) with high homology to cellular COX-2. In the current study, we show that vCOX-2 is expressed with early-gene kinetics during RhCMV infection, resulting in production of a 70-kDa protein. Consistent with the expression of a viral COX-2 isoform, cellular COX-2 expression was not induced during RhCMV infection. Finally, analysis of growth of recombinant RhCMV with vCOX-2 deleted identified vCOX-2 as a critical determinant for replication in endothelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.