ArticleClinical immunology (Orlando, Fla.)2004
Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases).
Article in Clinical immunology (Orlando, Fla.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.The New England journal of medicine · 2018Trial
- Fludarabine and 2-Gy TBI is superior to 2 Gy TBI as conditioning for HLA-matched related hematopoietic cell transplantation: a phase III randomized trial.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013Trial
- Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results.Bone marrow transplantation · 2012Trial
- Low-dose total body irradiation and fludarabine conditioning for HLA class I-mismatched donor stem cell transplantation and immunologic recovery in patients with hematologic malignancies: a multicenter trial.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2010Trial
- Thymic hyperplasia after autologous hematopoietic stem cell transplantation in multiple sclerosis: a case series.Frontiers in immunology · 2024Article
- Review
- Real-Life Experience of the Effects of Cladribine Tablets on Lymphocyte Subsets and Serum Neurofilament Light Chain Levels in Relapsing Multiple Sclerosis Patients.Brain sciences · 2022Article
- Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis.Frontiers in immunology · 2022Review
- Experimental Models of Infectious Pulmonary Complications Following Hematopoietic Cell Transplantation.Frontiers in immunology · 2021Review
- The role of innate immune cells in systemic sclerosis in the context of autologous hematopoietic stem cell transplantation.Clinical and experimental immunology · 2020Review
- The sialyltransferase ST3Gal-IV guides murine T-cell progenitors to the thymus.Blood advances · 2020Article
- Evaluating Thymic Function After Human Hematopoietic Stem Cell Transplantation in the Personalized Medicine Era.Frontiers in immunology · 2020Review
- Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures.Annals of the rheumatic diseases · 2019Article
- SR-BI (Scavenger Receptor Class B Type 1) Is Critical in Maintaining Normal T-Cell Development and Enhancing Thymic Regeneration.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Autologous Hematopoietic Stem Cell Transplantation for Treatment of Systemic Sclerosis.Frontiers in immunology · 2018Review
- Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants.Journal of autoimmunity · 2017Article
- National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017Review
- Review: Hematopoietic Stem Cell Transplantation for Scleroderma: Effective Immunomodulatory Therapy for Patients With Pulmonary Involvement.Arthritis & rheumatology (Hoboken, N.J.) · 2016Review
- Intrathecal IgG synthesis: a resistant and valuable target for future multiple sclerosis treatments.Multiple sclerosis international · 2015Review
- Factors influencing lymphocyte reconstitution after allogeneic hematopoietic stem cell transplantation in children.The Korean journal of hematology · 2012Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
To ascertain the consequences of severe leukopenia and the tempo of recovery, we studied the immunity of 56 adult patients treated for multiple sclerosis or systemic sclerosis with autologous CD34 cell transplantation using extremely lymphoablative conditioning. NK cell, monocyte, and neutrophil counts recovered to normal by 1 month; dendritic cell and B cell counts by 6 months; and T cell counts by 2 years posttransplant, although CD4 T cell counts remained borderline low. Initial peripheral expansion was robust for CD8 T cells but only moderate for CD4 T cells. Subsequent thymopoiesis was slow, especially in older patients. Importantly, levels of antibodies, including autoantibodies, did not drop substantially. Infections were frequent during the first 6 months, when all immune cells were deficient, and surprisingly rare (0.21 per patient year) at 7-24 months posttransplant, when only T cells (particularly CD4 T cells) were deficient. In conclusion, peripheral expansion of CD8 but not CD4 T cells is highly efficient. Prolonged CD4 lymphopenia is associated with relatively few infections, possibly due to antibodies produced by persisting pretransplant plasma cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.