ArticleProstate cancer and prostatic diseases2005
TGFBR1*6A is not associated with prostate cancer in men of European ancestry.
Article in Prostate cancer and prostatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Association between TGFBR1 polymorphisms and cancer risk: a meta-analysis of 35 case-control studies.PloS one · 2012Pooled it
- TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls.Molecular biology reports · 2010Pooled it
- Debate about TGFBR1 and the susceptibility to colorectal cancer.World journal of gastrointestinal oncology · 2012Article
- Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.The Prostate · 2009Article
- Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.Human genetics · 2007Article
- Characterization of novel transforming growth factor-beta type I receptors found in malignant pleural effusion tumor cells.BMC molecular biology · 2007Article
- Variants in the HEPSIN gene are associated with prostate cancer in men of European origin.Human genetics · 2006Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case-control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the (*)6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.