Evidence map›Paper›PMID 15505391›Full record

ReviewJournal of inherited metabolic disease2004

Challenges for basic research in glutaryl-CoA dehydrogenase deficiency.

S Kölker, K A Strauss, S I Goodman, G F Hoffmann, J G Okun, D M Koeller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of inherited metabolic disease, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Orthopaedic manifestations of glutaric acidemia Type 1.Journal of children's orthopaedics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

S KölkerDepartment of General Pediatrics, Division of Metabolic and Endocrine Diseases, University Children's Hospital Heidelberg, D-69120 Heidelberg, Germany. stefan_koelker@med.uni-heidelberg.de
K A Strauss
S I Goodman
G F Hoffmann
J G Okun
D M Koeller
Heidelberg University · DEClinic for Special Children · USOregon Health & Science University · USUniversity of Colorado Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the last decades, efforts have been made to elucidate the complex mechanisms underlying neuronal damage in glutaryl-CoA dehydrogenase deficiency. A combination of in vitro and in vivo investigations have facilitated the development of several hypotheses, including the probable pathogenic role of accumulating glutaric acid and 3-hydroxyglutaric acid. However, there are still many shortcomings that limit an evidence-based approach to treating this inborn error of metabolism. Major future goals should include generation of a suitable animal model for acute striatal necrosis, investigation of the formation, distribution and exact intra- and extracellular concentrations of accumulating metabolites, a deeper understanding of striatal vulnerability, and systematic investigation of effects on cerebral gene expression during development and of the modulatory role of inflammatory cytokines.

Indexed as

Amino Acid Metabolism, Inborn ErrorsAnimalsGlutaratesGlutaryl-CoA DehydrogenaseHumansNeostriatumNeuronsOxidoreductases Acting on CH-CH Group Donors3-hydroxyglutaric acidGlutaratesglutaric acidGlutaryl-CoA DehydrogenaseOxidoreductases Acting on CH-CH Group Donors

Identifiers

PMID15505391
OpenAlexW2051161882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.