ArticleAntimicrobial agents and chemotherapy2004
OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Metagenomic analysis of microbial communities and associated resistance genes, virulence genes, and mobile genetic elements in natural honey from Mu Cang Chai, Vietnam.World journal of microbiology & biotechnology · 2025Article
- Epidemiological and genomic characteristics ofMicrobiology spectrum · 2025Article
- Ralstonia pickettii: Two Cases of Bacteremia in a Moroccan Pediatric Intensive Care Unit.Cureus · 2025Article
- Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype.iScience · 2024Article
- NovelMicrobiology spectrum · 2024Article
- Complete sequence of carbapenem-resistantMicrobiology spectrum · 2024Article
- Differential effects of wastewater treatment plant effluents on the antibiotic resistomes of diverse river habitats.The ISME journal · 2023Article
- Clinical Manifestation ofJournal of Korean medical science · 2023Article
- Children with infectious pneumonia caused byWorld journal of clinical cases · 2023Article
- Bloodstream Infections Caused by Drug ResistantInfection and drug resistance · 2023Article
- Genomic analysis ofFrontiers in microbiology · 2023Article
- Peritoneal dialysis-associated peritonitis presenting with Ralstonia pickettii infection: A novel series of three cases during the COVID-19 pandemic.Seminars in dialysis · 2023Article
- Characterization of clinical Ralstonia strains and their taxonomic position.Antonie van Leeuwenhoek · 2021Article
- Identification and Elimination of the Clinically Relevant Multi-Resistant Environmental BacteriaMicroorganisms · 2020Article
- Longitudinal changes in the nasopharyngeal resistome of South African infants using shotgun metagenomic sequencing.PloS one · 2020Article
- Ralstonia mannitolilytica sepsis: a case report.Journal of medical case reports · 2019Article
- Article
- Nosocomial bloodstream infection and the emerging carbapenem-resistant pathogen Ralstonia insidiosa.BMC infectious diseases · 2019Article
- Article
- Genome Sequence of a Carbapenem-Resistant Strain of Ralstonia mannitolilytica.Genome announcements · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A chromosomally encoded oxacillinase, OXA-22, had been characterized from Ralstonia pickettii PIC-1 that did not explain by itself the resistance profile of this strain to beta-lactams. Thus, further analysis of the genetic background of this species led to the identification of another oxacillinase, OXA-60, that was expressed only after beta-lactam induction. This chromosomally encoded oxacillinase shared 19% amino acid identity with OXA-22. It has a narrow-spectrum hydrolysis profile that includes imipenem. OXA-60-like enzymes were identified in several R. pickettii strains. Gene inactivation and induction studies of the bla(OXA-60) and bla(OXA-22) genes in R. pickettii identified the relative contribution of each oxacillinase to the resistance profile of R. pickettii to beta-lactams.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.