ArticleNeuron2004
Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal.
Article in Neuron, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Capacitance Measurements of Exocytosis From AII Amacrine Cells in Retinal Slices.Bio-protocol · 2025Article
- GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.Cancer discovery · 2023Article
- Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity.ACS chemical neuroscience · 2021Article
- Distinct moieties underlie biphasic HFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Putting a brake on synaptic vesicle endocytosis.Cellular and molecular life sciences : CMLS · 2017Review
- Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels.Frontiers in cellular neuroscience · 2017Article
- The Contribution of L-Type CaFrontiers in molecular neuroscience · 2017Article
- Article
- Postsynaptic Plasticity Triggered by Ca²⁺-Permeable AMPA Receptor Activation in Retinal Amacrine Cells.Neuron · 2016Article
- Endogenous calcium buffering at photoreceptor synaptic terminals in salamander retina.Synapse (New York, N.Y.) · 2014Article
- The yin and yang of calcium effects on synaptic vesicle endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Synaptic mechanisms of adaptation and sensitization in the retina.Nature neuroscience · 2013Article
- Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synaptic vesicle endocytosis.Cold Spring Harbor perspectives in biology · 2012Review
- Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Allosteric modulation of retinal GABA receptors by ascorbic acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Endophilin drives the fast mode of vesicle retrieval in a ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Recovery from short-term depression and facilitation is ultrafast and Ca2+ dependent at auditory hair cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Synaptic release at mammalian bipolar cell terminals.Visual neuroscience · 2011Review
- Clathrin-mediated endocytosis at the synaptic terminal: bridging the gap between physiology and molecules.Traffic (Copenhagen, Denmark) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Although multiple kinetic components of synaptic vesicle endocytosis have been identified, it has remained unclear whether neurons can differentially modulate these components. Using membrane capacitance measurements from isolated goldfish bipolar cell terminals, we found that the kinetics of endocytosis in retinal slices (single exponential decay; tau > 10 s) were significantly slower than those in acutely dissociated terminals (double exponential decay; tau(fast) approximately 1-2 s; tau(slow) > 10 s). Surprisingly, GABA(A) and/or GABA(C) receptor antagonists restored the fast component of endocytosis to terminals in retinal slices. Blocking GABAergic feedback from reciprocal synapses or removing external Cl(-) ions also allowed for fast endocytosis. Elevating internal Cl(-) via the patch pipette invariably slowed endocytosis, even in terminals dialyzed with increased Ca(2+) buffer. These results suggest a new role for GABA and Cl(-) ions in blocking the trigger for fast endocytosis at this ribbon-type synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.