ArticleEmerging infectious diseases2004
Genetic and transmission analysis of Helicobacter pylori strains within a family.
Article in Emerging infectious diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.PloS one · 2013Trial
- Genetic Susceptibility toLife (Basel, Switzerland) · 2026Article
- Racial/ethnic differences in risk factors for non-cardia gastric cancer: an analysis of the Multiethnic Cohort (MEC) Study.Cancer causes & control : CCC · 2025Article
- Increasing our knowledge about the epidemiology ofInternational journal of circumpolar health · 2024Article
- Total worker healthCurrent opinion in epidemiology and public health · 2024Article
- A survey on the current status of Helicobacter pylori infection in households in Hainan Province, China.BMC gastroenterology · 2023Article
- Analysis of Genetic Relatedness between Gastric and OralInternational journal of molecular sciences · 2023Article
- Global Trend on Machine Learning inGlobal health, epidemiology and genomics · 2023Article
- Chinese Consensus Report on Family-BasedGut · 2022Article
- Comparison of invasive histological and molecular methods in the diagnosis ofF1000Research · 2022Article
- Global whole family based-World journal of gastroenterology · 2020Review
- Detection ofPathogens (Basel, Switzerland) · 2020Article
- Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins.Gastroenterology research and practice · 2020Article
- Inference from the analysis of genetic structure of Helicobacter pylori strains isolates from two paediatric patients with recurrent infection.BMC microbiology · 2019Article
- The use of stool specimens reveals Helicobacter pylori strain diversity in a cohort of adolescents and their family members in a developed country.International journal of medical microbiology : IJMM · 2018Article
- Diversification of theFrontiers in microbiology · 2016Article
- Article
- Analysis of Genomic Diversity among Helicobacter pylori Strains Isolated from Iranian Children by Pulsed Field Gel Electrophoresis.Iranian journal of pediatrics · 2014Article
- Diagnosis of Helicobacter pylori: what should be the gold standard?World journal of gastroenterology · 2014Review
- Population genetic analyses of Helicobacter pylori isolates from Gambian adults and children.PloS one · 2014Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To look for evidence of intrafamilial infection, we isolated 107 Helicobacter pylori clones from biopsied specimens taken from both parents and four children. We compared the sequences of two housekeeping genes (hspA and glmM) from these clones with those of 131 unrelated strains from patients living in different geographic regions. Strain relationships within the family were determined by analyzing allelic variation at both loci and building phylogenetic trees and by using multilocus sequence typing. Both hspA- and glmM-based phylogenetic trees showed East Asian and African branches. All samples from family members showed natural mixed infection. Identical alleles found in some strains isolated from the children and parents, but not in the strains isolated from unrelated patients, demonstrated that strains have circulated within the family. Several mechanisms, such as point mutations, intragenic recombination, and introduction of foreign (African) alleles, were shown to enhance strain diversity within the family.
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