ArticleCancer science2004
Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride.
Article in Cancer science, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
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- The effects of lead on the development of somites in chick embryos (Toxicology research · 2019Article
- Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer.BMC cancer · 2016Article
- Comparative DNA adduct formation and induction of colonic aberrant crypt foci in mice exposed to 2-amino-9H-pyrido[2,3-b]indole, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, and azoxymethane.Environmental and molecular mutagenesis · 2016Article
- Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium.Journal of toxicologic pathology · 2015Article
- Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon.Cancer science · 2014Article
- Colon preneoplastic lesions in animal models.Journal of toxicologic pathology · 2013Review
- Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development.PloS one · 2013Article
- Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer.Cancer science · 2012Article
- Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.Journal of biomedicine & biotechnology · 2011Review
- Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- A method for serial tissue processing and parallel analysis of aberrant crypt morphology, mucin depletion, and Beta-catenin staining in an experimental model of colon carcinogenesis.Biological procedures online · 2010Article
- Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept.Digestive diseases and sciences · 2008Article
- Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.Journal of carcinogenesis · 2006Article
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9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The usefulness of mucin-depleted foci (MDF), which have recently been proposed as a new preneoplastic biomarker in rat colon carcinogenesis, was histologically investigated in rat colonic tissues treated with 1,2-dimethylhydrazine dihydrochloride (DMH). The relationship among aberrant crypt foci (ACF), MDF and beta-catenin accumulated crypts (BCAC) was examined by comparing the corresponding computer-captured images. Twelve male F344 rats were given DMH s.c. at a dose of 40 mg/kg body weight, once a week for 2 weeks, and randomly divided into two groups. Rats in group 1 were given normal drinking water, while those in group 2 were given drinking water containing indomethacin (IND) at 16 ppm for 6 weeks. All animals were sacrificed 8 weeks after the first DMH treatment. The resected colons were fixed in 10% formalin, and stained with Alcian blue for observation of ACF and MDF. Histological and immunohistochemical analysis revealed that the numbers of ACF, MDF and overlapping lesions in group 2 (treated with IND) were significantly decreased, compared with those in group 1. The number of BCAC in group 2 was also significantly lower than that in group 1. The reduction (61.5%) of MDF by IND was much greater than that (29.3%) of ACF. Analyses of the computer-captured images indicated that MDF had more frequent dysplastic changes and overexpression of beta-catenin than did ACF. MDF having over 4 crypts or MDF with the appearance of ACF corresponded well to BCAC. These results suggest that MDF may be useful as an early biomarker in colon carcinogenesis.
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