ArticleIntensive care medicine2005
Dexamethasone decreases neurological sequelae and caspase activity.
Article in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Dexamethasone: a double-edged sword in the treatment of osteoarthritis.Scientific reports · 2025Article
- The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease.Molecules (Basel, Switzerland) · 2021Review
- Cerebral Oedema, Blood-Brain Barrier Breakdown and the Decrease in Na(+),K(+)-ATPase Activity in the Cerebral Cortex and Hippocampus are Prevented by Dexamethasone in an Animal Model of Maple Syrup Urine Disease.Molecular neurobiology · 2016Article
- A novel nitro-dexamethasone inhibits agr system activity and improves therapeutic effects in MRSA sepsis models without antibiotics.Scientific reports · 2016Article
- Prophylaxis of dexamethasone protects patients from further post-operative delirium after cardiac surgery: A randomized trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Antioxidant treatment prevents cognitive impairment and oxidative damage in pneumococcal meningitis survivor rats.Metabolic brain disease · 2012Article
- Predictors and clinical outcomes of postoperative delirium after administration of dexamethasone in patients undergoing coronary artery bypass surgery.International journal of preventive medicine · 2012Article
- Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells.Investigative ophthalmology & visual science · 2011Article
- Article
- Dexamethasone treatment reverses cognitive impairment but increases brain oxidative stress in rats submitted to pneumococcal meningitis.Oxidative medicine and cellular longevity · 2011Article
- Time-dependent behavioral recovery after pneumococcal meningitis in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Dexamethasone therapy and memory performance.Intensive care medicine · 2005Article
- Neurological outcome after bacterial meningitis: bridging the gap from molecules to behavior.Intensive care medicine · 2005Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the use of dexamethasone in a model of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables.
designRandomized, prospective animal study.
settingUniversity research laboratory. SUBJECTS: Male Wistar rats.
interventionsAnimals underwent a basilar cistern injection of either placebo or a suspension of Group B Streptococcus. Sixteen hours after inoculation, animals were randomized and received either dexamethasone or placebo in addition to antibiotics. Neurobehavioral performance and biological markers of brain injury were assessed at 3 days and 9 days after randomization. In a second experiment, caspase 1 and 3 were evaluated at 6 h, 24 h, and 72 h after dexamethasone administration. MEASUREMENTS AND MAIN
resultsNeurobehavioral performance at 3 days and 9 days was significantly improved in the dexamethasone group. Serum C-tau and cerebral edema were decreased after 3 days of dexamethasone treatment. Dexamethasone decreased Caspase 3 activation in meningitic animals.
conclusionThese findings demonstrate that dexamethasone decreases acute brain injury in a rat model of bacterial meningitis as measured by preservation of neurobehavioral performance.
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