ArticleBiophysical journal2005
Frequency encoding of T-cell receptor engagement dynamics in calcium time series.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Force-Induced Site-Specific Enzymatic Cleavage Probes Reveal That Serial Mechanical Engagement Boosts T Cell Activation.Journal of the American Chemical Society · 2024Article
- T-cell Receptor Is a Threshold Detector: Sub- and Supra-Threshold Stochastic Resonance in TCR-MHC Clusters on the Cell Surface.Entropy (Basel, Switzerland) · 2022Review
- Controlling T cells spreading, mechanics and activation by micropatterning.Scientific reports · 2021Article
- Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.Science signaling · 2019Article
- TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells.Frontiers in immunology · 2018Article
- Computational properties of mitochondria in T cell activation and fate.Open biology · 2016Review
- Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism.PloS one · 2016Article
- Barcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS).PLoS computational biology · 2013Article
- The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy.Frontiers in immunology · 2012Article
- Understanding the temporal codes of intra-cellular signals.Current opinion in genetics & development · 2010Review
- Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.Molecular cancer · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sustained increase of the cytosolic calcium concentration ([Ca2+]i) plays a central role in T-cell receptor (TCR)-mediated T-cell activation. Previous experiments using a [Ca2+]i clamp technique have demonstrated that specificity is encoded by the [Ca2+]i oscillation frequency since cytokine transcription factors are activated in a frequency-dependent manner. An outstanding question is how encoding of specific activation occurs under physiological conditions. In this case, continuous TCR interactions with specific peptides bound to cell surface-associated major histocompatibility complexes are driving the sustained [Ca2+]i increase. Addressing this question, we analyzed [Ca2+]i time series from individual T-cells mathematically. We are able to identify signal fluctuations associated with the TCR-triggering dynamics. We also find that [Ca2+]i time series associated with T-cells activated to IFN-gamma production exhibit oscillations with higher frequencies than the time series corresponding to T-cells not activated to IFN-gamma production. We show that signal autocorrelations are a means to distinguish functional signals according to their associated cytokine production. The signal level, however, allows for the distinction of nonfunctional from functional signals. These findings provide strong evidence for specificity encoding of biological functions in intracellular signals via signal level and signal correlations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.