ArticleInfection and immunity2004
Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Article
- Activation of the conserved Hippo kinases by inflammasome-triggered proteolytic cleavage controls programmed cell death in macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Sde phosphoribosyl-linked ubiquitin transferases protect theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR.Journal of leukocyte biology · 2022Article
- Knowledge to Predict Pathogens:Microorganisms · 2022Review
- Proteomic Analysis ofMolecular & cellular proteomics : MCP · 2020Article
- Viewing Legionella pneumophila Pathogenesis through an Immunological Lens.Journal of molecular biology · 2019Review
- Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria.Microbiology spectrum · 2019Review
- Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling.Veterinary sciences · 2016Review
- The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages.PloS one · 2016Article
- Regulated necrosis: the expanding network of non-apoptotic cell death pathways.Nature reviews. Molecular cell biology · 2014Review
- The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages.PloS one · 2014Article
- Inflammasome-mediated cell death in response to bacterial pathogens that access the host cell cytosol: lessons from legionella pneumophila.Frontiers in cellular and infection microbiology · 2013Review
- Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages.Infection and immunity · 2013Article
- A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.European journal of immunology · 2013Article
- Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection.mBio · 2013Article
- Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.Immunity · 2012Article
- Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation.Protein & cell · 2012Review
- Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes.The Journal of biological chemistry · 2011Article
- Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages.Frontiers in microbiology · 2011Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Although Legionella pneumophila can multiply in diverse cell types from a variety of species, macrophages from most inbred mouse strains are nonpermissive for intracellular replication and allow little or no growth of the bacteria. This phenomenon is likely genetically controlled by the mouse naip5 (birc1e) gene located within the Lgn1 locus. In this study, we have investigated the resistance of C57BL/6J macrophages to L. pneumophila infection by examining the fate of both the bacterium and the infected cells compared to that in macrophages from the permissive A/J strain. Our results indicate that although the trafficking of the L. pneumophila-containing vacuole is partially disrupted in C57BL/6J macrophages, this cannot account for the severity of the defect in intracellular growth observed in this strain. Infected macrophages are lost shortly after infection, and at later times a larger fraction of the C57BL/6J macrophages in which L. pneumophila undergoes replication are apoptotic compared to those derived from A/J mice. Finally, a loss of bacterial counts occurs after the first round of growth. Therefore, the resistance mechanism of C57BL/6J macrophages to L. pneumophila infection appears to be multifactorial, and we discuss how early and late responses result in clearing the infection.
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