ArticleImmunology2004
Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4+ CD8+ cells and B220+ T cells, in mice.
Article in Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation.Scientific reports · 2013Pooled it
- Intestinal T cells in aging: implications for gut barrier integrity and inflammaging.GeroScience · 2026Review
- Relationship between the appendix and ulcerative colitis: A new discovery.World journal of gastrointestinal endoscopy · 2026Review
- Dissecting the potential impact of appendectomy on colorectal cancer through metabolites and inflammatory proteins: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Clinical significance of the systemic immune-inflammation index in relation to pathology, treatment and outcomes in acute appendicitis: a retrospective study.Annals of medicine · 2025Article
- The association of appendectomy with prognosis and tumor-associated macrophages in patients with colorectal cancer.iScience · 2024Article
- The appendix and ulcerative colitis - an unsolved connection.Nature reviews. Gastroenterology & hepatology · 2023Review
- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- Article
- The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?Journal of Parkinson's disease · 2019Review
- Women who had appendectomy have increased risk of systemic lupus erythematosus: a nationwide cohort study.Clinical rheumatology · 2018Article
- Tissue-specific functions of invariant natural killer T cells.Nature reviews. Immunology · 2018Review
- The immunology of the vermiform appendix: a review of the literature.Clinical and experimental immunology · 2016Review
- The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms.The American journal of gastroenterology · 2016Review
- Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue.Immunity & ageing : I & A · 2014Article
- Natural killer T cells in adipose tissue are activated in lean mice.Experimental animals · 2013Article
- Biology of autoreactive extrathymic T cells and B-1 cells of the innate immune system.Immunologic research · 2012Review
- Lysozyme transgenic goats' milk positively impacts intestinal cytokine expression and morphology.Transgenic research · 2011Article
- Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa.Immunobiology · 2011Article
- Characterization of human invariant natural killer T cells expressing FoxP3.International immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The age-dependent variation in the proportion and number of lymphocyte subsets was examined at various extrathymic sites, including the liver, small intestine, colon and appendix in mice. In comparison with young mice (4 weeks of age), the number of total lymphocytes yielded by all tested organs was greater in adult (9 weeks) and old (40 weeks) mice. The major lymphocyte subset that expanded with age was interleukin-2 receptor (IL-2R) beta+ CD3int cells (50% of them expressed NK1.1) in the liver, whereas it was CD3+ IL-2Rbeta- NK1.1- cells at all intraepithelial sites in the intestine. Although NK1.1+ CD3+ cells were present at intraepithelial sites in the intestine, the proportion of this subset was rather low. The ratio of CD4 to CD8 tended to decrease among natural killer T (NKT) cells and T cells at all intraepithelial sites in the intestine with age. A unique population of double-positive CD4+ CD8+ cells in the small intestine increased in old mice. B220+ T cells were found mainly in the appendix and colon, and the proportion of these T cells decreased in old mice. Conventional NKT cells were very few in Jalpha281-/- and CD1d-/- mice in the liver, while NKT cells which existed in the appendix remained unchanged even in these mice. This was because unconventional CD8+ NKT cells were present in the intestine. The present results suggest that despite the fact that both the liver and intraepithelial sites in the intestine carry many extrathymic T cells, the distribution of lymphocyte subsets and their age-associated variation are site-specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.