ArticleEuropean journal of epidemiology2004
The Wheezing Illnesses Study Leidsche Rijn (WHISTLER): rationale and design.
Article in European journal of epidemiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.BMJ open respiratory research · 2024Pooled it
- E-health and consultation rates for respiratory illnesses in infants: a randomised clinical trial in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Trial
- Article
- Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence.JAMA network open · 2024Article
- Childhood infection burden, recent antibiotic exposure and vascular phenotypes in preschool children.PloS one · 2023Article
- Tracking Mental Wellbeing of Dutch Adolescents During the First Year of the COVID-19 Lockdown: A Longitudinal Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2022Article
- The Impact of the COVID-19 Outbreak on Mental Wellbeing in Children with a Chronic Condition Compared to Healthy Peers.International journal of environmental research and public health · 2022Article
- Birth cohort studies using symptom diaries for assessing respiratory diseases-a scoping review.PloS one · 2022Article
- Gender-Specific Changes in Life Satisfaction After the COVID-19-Related Lockdown in Dutch Adolescents: A Longitudinal Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021Article
- Risk factors for atopic diseases and recurrent respiratory tract infections in children.Pediatric pulmonology · 2020Article
- Defining asthma in children: how well do parents, doctors and spirometry agree?ERJ open research · 2020Article
- Relations between air pollution and vascular development in 5-year old children: a cross-sectional study in the Netherlands.Environmental health : a global access science source · 2019Article
- Long-chain polyunsaturated fatty acids in infant formula and cardiovascular markers in childhood.Maternal & child nutrition · 2018Article
- Detecting Acute Otitis Media Symptom Episodes Using a Mobile App: Cohort Study.JMIR mHealth and uHealth · 2017Article
- Feasibility and characteristics of arterial stiffness measurement in preschool children.European journal of preventive cardiology · 2017Article
- Antenatal coffee and tea consumption and the effect on birth outcome and hypertensive pregnancy disorders.PloS one · 2017Article
- E-health and health care behaviour of parents of young children: a qualitative study.Scandinavian journal of primary health care · 2016Article
- Maternal use of probiotics during pregnancy and effects on their offspring's health in an unselected population.European journal of pediatrics · 2016Article
- Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences.PloS one · 2016Article
- Relation Between Circulating Inflammatory Chemokines and Vascular Characteristics in Healthy, Young Children.Journal of the American Heart Association · 2015Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wheezing Illnesses Study Leidsche Rijn (WHISTLER) was initiated in December 2001 as a single-centre prospective birth cohort study and will include a population-based sample of at least 2000 healthy newborns. The aims of WHISTLER are to investigate determinants for wheezing illnesses (including neonatal lung function, viral infections, asthma-susceptibility genes and endotoxin exposure) and to derive a comprehensive risk score, that is appropriate for use in primary health care and allows for efficient planning of early preventive strategies. Baseline examination includes a questionnaire evaluating known risk factors for wheezing illnesses; anthropometric measurements; measurements of infant and parental lung function; and sampling of infant and parental DNA. Participants will be followed for respiratory events using data from a daily respiratory symptom questionnaire; visits to the general practitioner (primary health care visits, drugs prescriptions and hospital referral); viral sampling during wheezing episodes; and house dust sampling. Based on actual neonatal care practice and embedded in a larger epidemiological study, the Utrecht Health Project, WHISTLER will provide an unique framework to address issues in childhood respiratory disease that are currently insufficiently understood. In particular, WHISTLER will provide a well-balanced view on the prognostic power of neonatal lung function and genetic and environmental factors (including viral infections and endotoxin exposure) to predict wheezing illnesses from birth to young adulthood and beyond. In the scope of prevention, WHISTLER is expected to support the design of solid based prevention measures to reduce respiratory morbidity, mortality and associated costs, and to improve quality of life.
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