ArticleArchives of disease in childhood. Fetal and neonatal edition2004
Lipopolysaccharide binding protein in preterm infants.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Recent advances in the biosensing platforms for sepsis diagnosis.RSC advances · 2026Review
- Neonatal Sepsis.Sisli Etfal Hastanesi tip bulteni · 2020Review
- Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N.Scientific reports · 2018Article
- High Serum Lipopolysaccharide-Binding Protein Level in Chronic Hepatitis C Viral Infection Is Reduced by Anti-Viral Treatments.PloS one · 2017Article
- Use of early biomarkers in neonatal brain damage and sepsis: state of the art and future perspectives.BioMed research international · 2015Review
- Biomarkers for late-onset neonatal sepsis: cytokines and beyond.Clinics in perinatology · 2010Review
- Role of innate host defenses in susceptibility to early-onset neonatal sepsis.Clinics in perinatology · 2010Review
- Pathophysiology and treatment of septic shock in neonates.Clinics in perinatology · 2010Review
- Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children.Intensive care medicine · 2009Article
- Lipopolysaccharide-binding protein, lipopolysaccharide, and soluble CD14 in sepsis of critically ill neonates and children.Intensive care medicine · 2007Article
- Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection.Journal of perinatology : official journal of the California Perinatal Association · 2006Article
- Procalcitonin, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study.Critical care (London, England) · 2006Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess serum concentrations of lipopolysaccharide binding protein (LBP) in preterm infants with neonatal bacterial infection (NBI).
methodsBlood samples were analysed of 57 preterm (28(+1) to 36(+6), median 33(+2) weeks gestation) and 17 term infants admitted to the neonatal intensive care unit within the first 72 hours of life with suspicion of NBI. Samples were obtained at first suspicion of sepsis and after 12 and 24 hours. Diagnosis of NBI was confirmed by raised concentrations of C reactive protein and/or interleukin 6. The influence of gestational age and labour was analysed.
resultsMaximum LBP concentrations in infants with NBI were greatly increased compared with infants without NBI (13.0-46.0 microg/ml (median 20.0 microg/ml) v 0.6-17.4 microg/ml (median 4.2 microg/ml)). LBP concentrations in infected infants were not yet significantly raised when NBI was first suspected. The LBP concentrations of preterm infants were comparable to those of term infants. Regression analysis revealed no significant effect of labour or gestational age on LBP.
conclusionsRaised LBP concentrations indicate NBI in preterm and term infants. Preterm infants of > 28 weeks gestation seem to be capable of producing LBP as efficiently as term infants. Neonatal LBP concentrations are not influenced by labour. LBP may be a useful diagnostic marker of NBI in preterm infants.
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