ArticleEmerging infectious diseases2004
Genotyping, Orientalis-like Yersinia pestis, and plague pandemics.
Article in Emerging infectious diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights.Microorganisms · 2024Review
- Imprint of ancestral and modern threats in human mind - experience of fear, disgust, and anger.Frontiers in psychology · 2024Article
- Article
- Role of Goats in the Epidemiology ofBiology · 2022Review
- Correlating Genotyping Data ofPathogens (Basel, Switzerland) · 2021Article
- Biovar-related differences apparent in the flea foregut colonization phenotype of distinct Yersinia pestis strains do not impact transmission efficiency.Parasites & vectors · 2020Article
- Ancient dental pulp: Masterpiece tissue for paleomicrobiology.Molecular genetics & genomic medicine · 2020Review
- The Justinianic Plague: An inconsequential pandemic?Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- AncientProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
- Two thousand years of epidemics in Marseille and the Mediterranean Basin.New microbes and new infections · 2018Article
- Yersinia pestis halotolerance illuminates plague reservoirs.Scientific reports · 2017Article
- Environmental Microbial Forensics and Archaeology of Past Pandemics.Microbiology spectrum · 2017Review
- Archaeogenetics in evolutionary medicine.Journal of molecular medicine (Berlin, Germany) · 2016Review
- Whole genome multilocus sequence typing as an epidemiologic tool for Yersinia pestis.Diagnostic microbiology and infectious disease · 2016Article
- Diversity of human-associated Methanobrevibacter smithii isolates revealed by multispacer sequence typing.Current microbiology · 2015Article
- Enzootic plague foci, Algeria.New microbes and new infections · 2015Article
- 275 years since the epidemic of plague in Cluj: Dr. Alexandru Lenghel's contribution to its investigation.Clujul medical (1957) · 2015Article
- High-resolution typing of Leptospira interrogans strains by multispacer sequence typing.Journal of clinical microbiology · 2014Article
- Clinical detection and characterization of bacterial pathogens in the genomics era.Genome medicine · 2014Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Three pandemics have been attributed to plague in the last 1,500 years. Yersinia pestis caused the third, and its DNA was found in human remains from the second. The Antiqua biovar of Y. pestis may have caused the first pandemic; the other two biovars, Medievalis and Orientalis, may have caused the second and third pandemics, respectively. To test this hypothesis, we designed an original genotyping system based on intergenic spacer sequencing called multiple spacer typing (MST). We found that MST differentiated every biovar in a collection of 36 Y. pestis isolates representative of the three biovars. When MST was applied to dental pulp collected from remains of eight persons who likely died in the first and second pandemics, this system identified original sequences that matched those of Y. pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains.
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