Trial reportBMC neurology2004
Differential diagnosis of tuberculous meningitis from partially-treated pyogenic meningitis by cell ELISA.
Trial report in BMC neurology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The effect of machine learning algorithms in the prediction, and diagnosis of meningitis: A systematic review.Health science reports · 2024Review
- Rapid diagnosis and simultaneous identification of tuberculous and bacterial meningitis by a newly developed duplex polymerase chain reaction.Indian journal of microbiology · 2015Article
- CSF Proteins as Discreminatory Markers of Tubercular and Pyogenic Meningitis.Journal of clinical and diagnostic research : JCDR · 2013Article
- Serum and cerebrospinal fluid neuron-specific enolase for diagnosis of tuberculous meningitis.Yonsei medical journal · 2012Article
- Diagnostic value of early secreted antigenic target-6 for the diagnosis of tuberculous meningitis patients.Infection · 2009Article
- Central nervous system tuberculosis: pathogenesis and clinical aspects.Clinical microbiology reviews · 2008Review
- Evaluation of the IS6110 PCR assay for the rapid diagnosis of tuberculous meningitis.Cerebrospinal fluid research · 2007Article
- Comparative evaluation of early diagnosis of tuberculous meningitis by different assays.Journal of clinical microbiology · 2006Article
- Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis.Cerebrospinal fluid research · 2006Article
- Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients.Clinical and diagnostic laboratory immunology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTuberculous meningitis (TBM) is a major global health problem, and it is sometimes difficult to perform a differential diagnosis of this disease from other diseases, particularly partially-treated pyogenic meningitis (PTPM). In an earlier study, we demonstrated the presence of a 30-kD protein antigen in cerebrospinal fluid (CSF) of TBM patients. We have also shown that lymphocytes from CSF of TBM patients respond differently to this antigen than do those from PTPM patients. The purpose of this study was to develop an assay that can discriminate between TBM and PTPM.
methodsWe developed a cell enzyme-linked immunosorbant assay (Cell ELISA) to quantitatively measure production of antibodies against the 30-kD protein in B cells from CSF of TBM and PTPM patients.
resultsThe cell ELISA yielded 92% (11/12) sensitivity and 92% (11/12) specificity for the differential diagnosis of TBM from PTPM.
conclusionWhen induced with the 30-kD protein antigen, B cells derived from CSF of TBM patients respond to IgG production within 24 h while those derived from PTPM patients do not respond.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.