Class switching and Myc translocation: how does DNA break?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.Frontiers in immunology · 2015
   Article
2. MicroRNAs in lupus.Autoimmunity · 2014
   Review
3. Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.Frontiers in immunology · 2012
   Article
4. Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Molecular immunology · 2011
   Article
5. The multi-systemic nature of diabetes mellitus: Genotype or phenotype?North American journal of medical sciences · 2010
   Article
6. Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Autoimmunity · 2009
   Article
7. AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Molecular immunology · 2008
   Article
8. A role for DRAK2 in the germinal center reaction and the antibody response.Autoimmunity · 2008
   Article
9. Impaired DNA damage checkpoint response in MIF-deficient mice.The EMBO journal · 2007
   Article
10. Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.Molecular cell · 2006
    Article
11. DNA repair in antibody somatic hypermutation.Trends in immunology · 2006
    Review
12. A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.Journal of immunology (Baltimore, Md. : 1950) · 2006
    Article
13. The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.The EMBO journal · 2005
    Article
14. DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.Annals of the New York Academy of Sciences · 2005
    Review

Corrections and comments

• Comment on
  Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.2004

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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