ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Action potential backpropagation and multiglomerular signaling in the rat vomeronasal system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- The Slow Dynamics of Intracellular Sodium Concentration Increase the Time Window of Neuronal Integration: A Simulation Study.Frontiers in computational neuroscience · 2017Article
- Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Prolonged Intracellular Na+ Dynamics Govern Electrical Activity in Accessory Olfactory Bulb Mitral Cells.PLoS biology · 2015Article
- Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators.Frontiers in cellular neuroscience · 2014Article
- Cholecystokinin: an excitatory modulator of mitral/tufted cells in the mouse olfactory bulb.PloS one · 2013Article
- Correlated firing in tufted cells of mouse olfactory bulb.Neuroscience · 2010Article
- Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper(II) fluorescent probe.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Calcium buffering in rodent olfactory bulb granule cells and mitral cells.The Journal of physiology · 2009Article
- Subthreshold glutamate release from mitral cell dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Calcium permeable AMPA receptors and autoreceptors in external tufted cells of rat olfactory bulb.Neuroscience · 2007Article
- Tuft calcium spikes in accessory olfactory bulb mitral cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the accessory olfactory bulb (AOB), sensory neurons expressing a given vomeronasal receptor (VR) gene send divergent projections to many glomeruli, and second-order neurons (mitral cells) link to multiple glomeruli via branched primary dendrites. We used calcium imaging and paired somadendritic patch-clamp recording to track backpropagated action potentials (APs) in rat AOB primary dendrites. In cells loaded with 150 microm Calcium Orange, somatic spikes elicited fluorescence transients over the entire primary dendritic tree, and the relative fluorescence increment DeltaF/F(0) increased along all branches from soma to glomeruli. Backpropagation was reliant on Na+ channels: in 1 microm TTX, somatic AP commands evoked dendritic Ca2+ transients that declined steeply with distance. In paired soma- dendritic whole-cell recordings, backpropagated APs were unattenuated up to approximately 200 microm from the soma, whereas subthreshold voltage transients decayed markedly. Computational modeling indicated that the large distal Ca2+ transients are consistent with active, not passive, backpropagation. Genetic tracing in the AOB has suggested homotypic connectivity with individual mitral cell dendritic arbors projecting only to glomeruli targeted by sensory neurons expressing the same VR gene. Non-decremental, non-dichotomous backpropagation in AOB primary dendrites ensures fast, reliable communication between mitral cells and their homotypic glomeruli, binding them into functional modules in accordance with their VR-coded inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.